New Lipophilic Derivatives of AZT and d4T 5′-Phosphonates

5′-Aminocarbonylphosphonyl and aminocarbonylmethylphosphonyl diesters of AZT and d4T were synthesized as potential anti-HIV agents.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.981-985
Main Authors: Shirokova, Elena A., Jasko, Maxim V., Khandazhinskaya, Anastasiya L., Yanvarev, Dmitry V., Skoblov, Yury S., Pronayeva, Tatyana R., Fedyuk, Nina V., Pokrovsky, Andrey G., Kukhanova, Marina K.
Format: Article
Language:English
Subjects:
Anti-HIV agents
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - chemistry
Anti-HIV Agents - pharmacology
AZT and d4T derivatives
Cell Division - drug effects
Cell Line
Cells, Cultured
Drug Stability
Half-Life
HIV-1 - drug effects
Humans
Hydrogen-Ion Concentration
Hydrolysis
Nucleoside 5′-phosphonates
Organophosphonates
Stavudine - analogs & derivatives
Stavudine - chemical synthesis
Stavudine - chemistry
Stavudine - pharmacology
Structure-Activity Relationship
Virus Replication - drug effects
Zidovudine - analogs & derivatives
Zidovudine - chemical synthesis
Zidovudine - chemistry
Zidovudine - pharmacology
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Description
Summary:5′-Aminocarbonylphosphonyl and aminocarbonylmethylphosphonyl diesters of AZT and d4T were synthesized as potential anti-HIV agents.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-120022718