Bacterial otitis media: a new non-invasive rat model

This study describes the development of a physiological rat model for otitis media. The model is based on the assumption that bacteria, intranasally introduced into the nasopharynx, will be transferred into the middle ear cavity during swallowing provided that the ambient air pressure is higher than...

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Bibliographic Details
Published in:Vaccine 2003-11, Vol.21 (31), p.4539-4544
Main Authors: Tonnaer, Edith L.G.M, Sanders, Elisabeth A.M, Curfs, Jo H.A.J
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial diseases
Bacterial Translocation
Biological and medical sciences
Coloring Agents
Disease Models, Animal
Ear diseases
Ear, Middle - microbiology
Ear, Middle - pathology
Eardrum
Evans Blue
Experimental bacterial diseases and models
Experiments
Female
Infectious diseases
Laboratory animals
Medical sciences
Membranes
Nasopharynx - microbiology
Otitis media
Otitis Media - microbiology
Otitis Media - pathology
Otitis Media with Effusion - microbiology
Otitis Media with Effusion - pathology
Pathogenesis
Pneumococcal Infections - microbiology
Pneumococcal Infections - pathology
Posture
Pressure
Pressure changes
Ratmodel
Rats
Rats, Inbred Lew
Rodents
Streptococcus infections
Viscosity
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Summary:This study describes the development of a physiological rat model for otitis media. The model is based on the assumption that bacteria, intranasally introduced into the nasopharynx, will be transferred into the middle ear cavity during swallowing provided that the ambient air pressure is higher than the middle ear pressure. This model demonstrates that small pressure changes, generated in a pressure cabin under controlled conditions, can be used as driving force for the transfer of bacteria into the middle ear cavity resulting in bilateral otitis media. Because invasive techniques or biochemical agents are not applied, this model is suited to investigate immunological aspects of otitis media, including the effects of vaccination.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00501-2