Influences of Ovariectomy on Experimental Tooth Movement in the Rat

Estrogen withdrawal, which is important in the pathogenesis of post-menopausal osteoporosis, accelerates bone metabolism with a negative calcium balance. Therefore, it is hypothesized that estrogen deficiency could affect the rate of experimental tooth movement and alveolar bone remodeling. Six-week...

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Bibliographic Details
Published in:Journal of dental research 2001-09, Vol.80 (9), p.1858-1861
Main Authors: Yamashiro, T., Takano-Yamamoto, T.
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - etiology
Alveolar Bone Loss - metabolism
Alveolar Process - metabolism
Alveolar Process - pathology
Animals
Bone Density
Bone Diseases, Metabolic - etiology
Decalcification Technique
Dentistry
Estrogens - deficiency
Female
Maxillary Diseases - etiology
Maxillary Diseases - metabolism
Osteoblasts - pathology
Osteoclasts - pathology
Osteoporosis - physiopathology
Ovariectomy
Ovary - physiology
Rats
Rats, Sprague-Dawley
Tooth Movement Techniques - adverse effects
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Summary:Estrogen withdrawal, which is important in the pathogenesis of post-menopausal osteoporosis, accelerates bone metabolism with a negative calcium balance. Therefore, it is hypothesized that estrogen deficiency could affect the rate of experimental tooth movement and alveolar bone remodeling. Six-week-old rats received a bilateral ovariectomy (OVX) or sham operation. Fourteen days later, rats were subjected to lateral tooth movement in the upper molar with nickel-titanium wire of 10 g of force. OVX significantly increased the rate of experimental tooth movement from 12 days after experimental tooth movement (p < 0.001). Eighteen days after the start of tooth movement, bone histomorphometry demonstrated that OVX significantly elevated the osteoblast surface, osteoclast surface, and number of osteoclasts (p < 0.05) in the alveolar bone. These findings indicated that estrogen deficiency caused significantly rapid orthodontic tooth movement, and that the acceleration of tooth movement could be due to the further activation of alveolar bone turnover.
ISSN:0022-0345
1544-0591
DOI:10.1177/00220345010800091701