Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines

β -D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effe...

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Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2003-10, Vol.22 (5-8), p.605-609
Main Authors: Mathé, Christophe, Lioux, Thierry, Gosselin, Gilles
Format: Article
Language:English
Subjects:
Adenine - analogs & derivatives
Adenine - chemical synthesis
Adenine - chemistry
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - chemistry
Anti-HIV Agents - pharmacology
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Azides - chemical synthesis
Azido-tetrazolo tautomerism
Hepatitis B virus - drug effects
HIV - drug effects
Indicators and Reagents
Models, Molecular
Molecular Conformation
Nucleoside analogues
Purines - chemical synthesis
Purines - chemistry
Stereoisomerism
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description β -D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effect.
doi_str_mv 10.1081/NCN-120021964
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source Taylor and Francis Science and Technology Collection
subjects Adenine - analogs & derivatives
Adenine - chemical synthesis
Adenine - chemistry
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - chemistry
Anti-HIV Agents - pharmacology
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Azides - chemical synthesis
Azido-tetrazolo tautomerism
Hepatitis B virus - drug effects
HIV - drug effects
Indicators and Reagents
Models, Molecular
Molecular Conformation
Nucleoside analogues
Purines - chemical synthesis
Purines - chemistry
Stereoisomerism
title Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines
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