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Effect of nebulized furosemide in terminally ill cancer patients with dyspnea
We evaluated the effect of ultrasonically nebulized furosemide (20 mg) on dyspnea uncontrollable by standard therapy in patients with terminal cancer. Dyspnea was evaluated using the Cancer Dyspnea Scale (CDS) before and 60 min after inhalation. Changes in arterial blood gases, hemoglobin oxygen sat...
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| Published in: | Journal of pain and symptom management 2003-10, Vol.26 (4), p.962-967 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c438t-964580487456b9c3ce2422800c44245b21eb13a7283358af7aaa02f464bb5e793 |
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| cites | cdi_FETCH-LOGICAL-c438t-964580487456b9c3ce2422800c44245b21eb13a7283358af7aaa02f464bb5e793 |
| container_end_page | 967 |
| container_issue | 4 |
| container_start_page | 962 |
| container_title | Journal of pain and symptom management |
| container_volume | 26 |
| creator | Kohara, Hiroyuki Ueoka, Hiroshi Aoe, Keisuke Maeda, Tadashi Takeyama, Hiroyasu Saito, Ryusei Shima, Yasuo Uchitomi, Yosuke |
| description | We evaluated the effect of ultrasonically nebulized furosemide (20 mg) on dyspnea uncontrollable by standard therapy in patients with terminal cancer. Dyspnea was evaluated using the Cancer Dyspnea Scale (CDS) before and 60 min after inhalation. Changes in arterial blood gases, hemoglobin oxygen saturation (SpO
2), heart rate (HR), and respiratory rate (RR) also were evaluated. In 12 of 15 patients (80%), total dyspnea scores by CDS improved significantly after inhalation of furosemide (
P
=
0.007), especially concerning a reduced sense of effort (
P
=
0.013) and reduced anxiety (
P
=
0.04). No significant changes were observed in the partial pressure of oxygen in arterial blood (PaO
2), the partial pressure of carbon dioxide in arterial blood (PaCO
2), SpO
2, HR, or RR. Inhalation of nebulized furosemide appears to be effective against dyspnea in terminally ill cancer patients. |
| doi_str_mv | 10.1016/S0885-3924(03)00322-1 |
| format | article |
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2), heart rate (HR), and respiratory rate (RR) also were evaluated. In 12 of 15 patients (80%), total dyspnea scores by CDS improved significantly after inhalation of furosemide (
P
=
0.007), especially concerning a reduced sense of effort (
P
=
0.013) and reduced anxiety (
P
=
0.04). No significant changes were observed in the partial pressure of oxygen in arterial blood (PaO
2), the partial pressure of carbon dioxide in arterial blood (PaCO
2), SpO
2, HR, or RR. Inhalation of nebulized furosemide appears to be effective against dyspnea in terminally ill cancer patients.</description><identifier>ISSN: 0885-3924</identifier><identifier>EISSN: 1873-6513</identifier><identifier>DOI: 10.1016/S0885-3924(03)00322-1</identifier><identifier>PMID: 14575057</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; cancer ; Cancer Dyspnea Scale ; Chloride Channels - antagonists & inhibitors ; Clinical death. Palliative care. Organ gift and preservation ; Critical Illness - therapy ; Dyspnea ; Dyspnea - drug therapy ; Dyspnea - etiology ; Furosemide - administration & dosage ; Humans ; Medical sciences ; nebulized furosemide ; Nebulizers and Vaporizers ; Neoplasms - complications ; Ultrasonics</subject><ispartof>Journal of pain and symptom management, 2003-10, Vol.26 (4), p.962-967</ispartof><rights>2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-964580487456b9c3ce2422800c44245b21eb13a7283358af7aaa02f464bb5e793</citedby><cites>FETCH-LOGICAL-c438t-964580487456b9c3ce2422800c44245b21eb13a7283358af7aaa02f464bb5e793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15201078$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14575057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kohara, Hiroyuki</creatorcontrib><creatorcontrib>Ueoka, Hiroshi</creatorcontrib><creatorcontrib>Aoe, Keisuke</creatorcontrib><creatorcontrib>Maeda, Tadashi</creatorcontrib><creatorcontrib>Takeyama, Hiroyasu</creatorcontrib><creatorcontrib>Saito, Ryusei</creatorcontrib><creatorcontrib>Shima, Yasuo</creatorcontrib><creatorcontrib>Uchitomi, Yosuke</creatorcontrib><title>Effect of nebulized furosemide in terminally ill cancer patients with dyspnea</title><title>Journal of pain and symptom management</title><addtitle>J Pain Symptom Manage</addtitle><description>We evaluated the effect of ultrasonically nebulized furosemide (20 mg) on dyspnea uncontrollable by standard therapy in patients with terminal cancer. Dyspnea was evaluated using the Cancer Dyspnea Scale (CDS) before and 60 min after inhalation. Changes in arterial blood gases, hemoglobin oxygen saturation (SpO
2), heart rate (HR), and respiratory rate (RR) also were evaluated. In 12 of 15 patients (80%), total dyspnea scores by CDS improved significantly after inhalation of furosemide (
P
=
0.007), especially concerning a reduced sense of effort (
P
=
0.013) and reduced anxiety (
P
=
0.04). No significant changes were observed in the partial pressure of oxygen in arterial blood (PaO
2), the partial pressure of carbon dioxide in arterial blood (PaCO
2), SpO
2, HR, or RR. Inhalation of nebulized furosemide appears to be effective against dyspnea in terminally ill cancer patients.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>cancer</subject><subject>Cancer Dyspnea Scale</subject><subject>Chloride Channels - antagonists & inhibitors</subject><subject>Clinical death. Palliative care. Organ gift and preservation</subject><subject>Critical Illness - therapy</subject><subject>Dyspnea</subject><subject>Dyspnea - drug therapy</subject><subject>Dyspnea - etiology</subject><subject>Furosemide - administration & dosage</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>nebulized furosemide</subject><subject>Nebulizers and Vaporizers</subject><subject>Neoplasms - complications</subject><subject>Ultrasonics</subject><issn>0885-3924</issn><issn>1873-6513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqF0M9PFDEUwPGGSGBF_wRMLxo9jL7-mnZPxBBAEogH9dx0Oq-hpjOztjOa5a-nsBs5curl-17bDyGnDD4zYO2XH2CMasSay48gPgEIzht2QFbMaNG0iolXZPU_OSavS_kNAEq04ogcM6m0AqVX5PYiBPQznQIdsVtSvMeehiVPBYfYI40jnTEPcXQpbWlMiXo3esx04-aI41zovzjf0X5bNiO6N-QwuFTw7f48Ib8uL36ef2tuvl9dn3-9abwUZm7WrVQGpNFStd3aC49ccm4AvJRcqo4z7JhwmhshlHFBO-eAB9nKrlOo1-KEfNjt3eTpz4JltkMsHlNyI05LsZoJUNDyGqpd6OuPSsZgNzkOLm8tA_voaJ8c7SOSBWGfHC2rc-_2FyzdgP3z1B6uBu_3gSvepZCrSizPneLAQJvane06rBx_I2ZbfHXz2Mdc3W0_xRee8gBasI4G</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Kohara, Hiroyuki</creator><creator>Ueoka, Hiroshi</creator><creator>Aoe, Keisuke</creator><creator>Maeda, Tadashi</creator><creator>Takeyama, Hiroyasu</creator><creator>Saito, Ryusei</creator><creator>Shima, Yasuo</creator><creator>Uchitomi, Yosuke</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Effect of nebulized furosemide in terminally ill cancer patients with dyspnea</title><author>Kohara, Hiroyuki ; Ueoka, Hiroshi ; Aoe, Keisuke ; Maeda, Tadashi ; Takeyama, Hiroyasu ; Saito, Ryusei ; Shima, Yasuo ; Uchitomi, Yosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-964580487456b9c3ce2422800c44245b21eb13a7283358af7aaa02f464bb5e793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>cancer</topic><topic>Cancer Dyspnea Scale</topic><topic>Chloride Channels - antagonists & inhibitors</topic><topic>Clinical death. Palliative care. Organ gift and preservation</topic><topic>Critical Illness - therapy</topic><topic>Dyspnea</topic><topic>Dyspnea - drug therapy</topic><topic>Dyspnea - etiology</topic><topic>Furosemide - administration & dosage</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>nebulized furosemide</topic><topic>Nebulizers and Vaporizers</topic><topic>Neoplasms - complications</topic><topic>Ultrasonics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kohara, Hiroyuki</creatorcontrib><creatorcontrib>Ueoka, Hiroshi</creatorcontrib><creatorcontrib>Aoe, Keisuke</creatorcontrib><creatorcontrib>Maeda, Tadashi</creatorcontrib><creatorcontrib>Takeyama, Hiroyasu</creatorcontrib><creatorcontrib>Saito, Ryusei</creatorcontrib><creatorcontrib>Shima, Yasuo</creatorcontrib><creatorcontrib>Uchitomi, Yosuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pain and symptom management</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kohara, Hiroyuki</au><au>Ueoka, Hiroshi</au><au>Aoe, Keisuke</au><au>Maeda, Tadashi</au><au>Takeyama, Hiroyasu</au><au>Saito, Ryusei</au><au>Shima, Yasuo</au><au>Uchitomi, Yosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of nebulized furosemide in terminally ill cancer patients with dyspnea</atitle><jtitle>Journal of pain and symptom management</jtitle><addtitle>J Pain Symptom Manage</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>26</volume><issue>4</issue><spage>962</spage><epage>967</epage><pages>962-967</pages><issn>0885-3924</issn><eissn>1873-6513</eissn><abstract>We evaluated the effect of ultrasonically nebulized furosemide (20 mg) on dyspnea uncontrollable by standard therapy in patients with terminal cancer. Dyspnea was evaluated using the Cancer Dyspnea Scale (CDS) before and 60 min after inhalation. Changes in arterial blood gases, hemoglobin oxygen saturation (SpO
2), heart rate (HR), and respiratory rate (RR) also were evaluated. In 12 of 15 patients (80%), total dyspnea scores by CDS improved significantly after inhalation of furosemide (
P
=
0.007), especially concerning a reduced sense of effort (
P
=
0.013) and reduced anxiety (
P
=
0.04). No significant changes were observed in the partial pressure of oxygen in arterial blood (PaO
2), the partial pressure of carbon dioxide in arterial blood (PaCO
2), SpO
2, HR, or RR. Inhalation of nebulized furosemide appears to be effective against dyspnea in terminally ill cancer patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14575057</pmid><doi>10.1016/S0885-3924(03)00322-1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-3924 |
| ispartof | Journal of pain and symptom management, 2003-10, Vol.26 (4), p.962-967 |
| issn | 0885-3924 1873-6513 |
| language | eng |
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| source | Elsevier |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences cancer Cancer Dyspnea Scale Chloride Channels - antagonists & inhibitors Clinical death. Palliative care. Organ gift and preservation Critical Illness - therapy Dyspnea Dyspnea - drug therapy Dyspnea - etiology Furosemide - administration & dosage Humans Medical sciences nebulized furosemide Nebulizers and Vaporizers Neoplasms - complications Ultrasonics |
| title | Effect of nebulized furosemide in terminally ill cancer patients with dyspnea |
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