Multiple Genotypes of Nonpathogenic H6N2 Influenza Viruses Isolated from Chickens in California

From February 2000 through September 2001, a limited number of H6N2 influenza viruses were isolated from chickens in California. This report describes the genetic characterization of nine of these H6N2 viruses. All of the viruses analyzed had phylogenetically similar hemagglutinin (HA) and neuramini...

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Bibliographic Details
Published in:Avian diseases 2003-01, Vol.47 (s3), p.905-910
Main Authors: Webby, R. J, Woolcock, P. R, Krauss, S. L, Walker, D. B, Chin, P. S, Shortridge, K. F, Webster, R. G
Format: Article
Language:English
Subjects:
Advances in Molecular Biology and Molecular Epidemiology
Amino Acid Sequence
Animals
Asia
avian influenza
California
Chickens
Chickens - virology
DNA, Viral - genetics
Ducks
Europe
Evolution
Genotype
Genotypes
H6N2
Hemagglutinins, Viral - genetics
influenza
Influenza A virus
Influenza A virus - classification
Influenza A virus - genetics
Influenza A virus - isolation & purification
interspecies transmission
Molecular Sequence Data
Neuraminidase - genetics
North America
Oral Presentations: Advances in Molecular Biology and Molecular Epidemiology—Moderator: Stacey Schultz-Cherry
Orthomyxoviridae
Phylogenetics
Phylogeny
Polymerase chain reaction
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - genetics
RNA, Viral - isolation & purification
Viral Proteins - chemistry
Viral Proteins - genetics
Viruses
Waterfowl
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Summary:From February 2000 through September 2001, a limited number of H6N2 influenza viruses were isolated from chickens in California. This report describes the genetic characterization of nine of these H6N2 viruses. All of the viruses analyzed had phylogenetically similar hemagglutinin (HA) and neuraminidase molecules that suggested the viruses shared a recent common ancestor. The analysis of the HA sequence of these viruses with all available H6 viruses from different hosts and locations showed that these genes do not separate into well-defined North American and Eurasian lineages. The neuraminidase genes of the California viruses contain an 18 amino acid deletion, a possible adaptation to growth in chickens. Analysis of the remaining gene segments of the California viruses revealed that three distinct genotypes of H6N2 viruses were present.
ISSN:0005-2086
1938-4351
DOI:10.1637/0005-2086-47.s3.905