Zebrafish pronephros: A model for understanding cystic kidney disease

The embryonic kidney of the zebrafish is the pronephros. The ease of genetic analysis and experimentation in zebrafish, coupled with the simplicity of the pronephros, make the zebrafish an ideal model system for studying kidney development and function. Several mutations have been isolated in zebraf...

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Bibliographic Details
Published in:Developmental dynamics 2003-11, Vol.228 (3), p.514-522
Main Authors: Hostetter, Christine L., Sullivan‐Brown, Jessica L., Burdine, Rebecca D.
Format: Article
Language:English
Subjects:
Animals
asymmetry
Body Patterning - physiology
cystic
Danio rerio
kidney
Kidney - abnormalities
Kidney - embryology
Kidney Diseases, Cystic
Models, Animal
Morphogenesis
pronephros
zebrafish
Zebrafish - embryology
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Summary:The embryonic kidney of the zebrafish is the pronephros. The ease of genetic analysis and experimentation in zebrafish, coupled with the simplicity of the pronephros, make the zebrafish an ideal model system for studying kidney development and function. Several mutations have been isolated in zebrafish genetic screens that result in cyst formation in the pronephros. Cloning and characterization of these mutations will provide insight into kidney development but may also provide understanding of the molecular basis of cystic kidney diseases. In this review, we focus on the zebrafish as a model for understanding cystic kidney disease and the links between cystic kidney disease and left–right patterning. Developmental Dynamics, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.10371