Detection of cryptic MLL insertions using a commercial dual-color fluorescence in situ hybridization probe

Involvement of the MLL gene located at chromosome region 11q23 is a frequent occurrence in both acute myelocytic leukemia and acute lymphoblastic leukemia. More than 30 loci have now been associated with MLL, usually by reciprocal translocation. Deletions, insertions, and more complex rearrangements...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2003-11, Vol.147 (1), p.81-83
Main Authors: Dyson, Michael J., Talley, Polly J., Reilly, John T., Stevenson, David, Parsons, Emma, Tighe, Jane
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Bone Marrow Cells - pathology
Chromosome Mapping
Chromosomes, Human, Pair 11 - genetics
DNA Transposable Elements - genetics
DNA-Binding Proteins - genetics
Female
Gene Rearrangement
General aspects. Genetic counseling
Histone-Lysine N-Methyltransferase
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - pathology
Male
Medical genetics
Medical sciences
Middle Aged
Myeloid-Lymphoid Leukemia Protein
Proto-Oncogenes
Telomere - genetics
Transcription Factors
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Summary:Involvement of the MLL gene located at chromosome region 11q23 is a frequent occurrence in both acute myelocytic leukemia and acute lymphoblastic leukemia. More than 30 loci have now been associated with MLL, usually by reciprocal translocation. Deletions, insertions, and more complex rearrangements of MLL are rarely seen. We present three cases of AML M5 showing no cytogenetic evidence of 11q23 rearrangement, in which a commercial MLL dual-color fluorescence in situ hybrdization probe revealed a nonstandard abnormal signal pattern, suggesting cryptic insertion of the MLL gene into its partner gene site.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(03)00158-4