Cardiac angiotensin-(1-7) in ischemic cardiomyopathy

Accumulating evidence suggests that angiotensin-(1-7) (Ang-[1-7]) may play an important role in counteracting the pressor, proliferative, and profibrotic actions of angiotensin II in the heart. Thus, we evaluated whether Ang-(1-7) is expressed in the myocardium of normal rats and those in which myoc...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2003-10, Vol.108 (17), p.2141-2146
Main Authors: AVERILL, David B, ISHIYAMA, Yuichiro, CHAPPELL, Mark C, FERRARIO, Carlos M
Format: Article
Language:English
Subjects:
Angiotensin I - biosynthesis
Animals
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiomyopathies - etiology
Cardiomyopathies - pathology
Cardiomyopathies - physiopathology
Disease Models, Animal
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Hemodynamics
Immunohistochemistry
Ligation
Male
Medical sciences
Myocardial Ischemia - complications
Myocardial Ischemia - pathology
Myocardial Ischemia - physiopathology
Myocardium - metabolism
Myocardium - pathology
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Peptide Fragments - biosynthesis
Rats
Rats, Inbred Lew
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Summary:Accumulating evidence suggests that angiotensin-(1-7) (Ang-[1-7]) may play an important role in counteracting the pressor, proliferative, and profibrotic actions of angiotensin II in the heart. Thus, we evaluated whether Ang-(1-7) is expressed in the myocardium of normal rats and those in which myocardial infarction was produced 4 weeks beforehand. The left coronary artery in 10-week-old Lewis rats was either ligated (n=5) or exposed but not occluded in age-matched controls (sham; n=5). Left ventricular end-diastolic pressures were significantly elevated 4 weeks after myocardial infarction (25+/-1 versus 5+/-1 mm Hg for sham; P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.0000092888.63239.54