Augmented PLA2 activity in pre-eclamptic decidual tissue: A key player in the pathophysiology of 'acute atherosis' in pre-eclampsia?

Decidual acute atherosis is associated with pre-eclampsia, but the underlying mechanism is still unclear. We have previously demonstrated elevated level of the oxidative stress marker 8-isoprostaglandin F(2 alpha)(8-isoprostane) and lipids in pre-eclamptic decidual tissue. Arachidonic acid (AA) in t...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2003-11, Vol.24 (10), p.965-973
Main Authors: STAFF, A. C, RANHEIM, T, HALVORSEN, B
Format: Article
Language:English
Subjects:
Apolipoproteins B - analysis
Arachidonic Acid - analysis
Arteriosclerosis - etiology
Biological and medical sciences
Body Mass Index
Cytosol - chemistry
Deciduoma - chemistry
Deciduoma - enzymology
Diseases of mother, fetus and pregnancy
Fatty Acids - analysis
Female
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Phospholipases A - metabolism
Phospholipases A2
Pre-Eclampsia - complications
Pre-Eclampsia - enzymology
Pregnancy
Pregnancy. Fetus. Placenta
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal Transduction
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Summary:Decidual acute atherosis is associated with pre-eclampsia, but the underlying mechanism is still unclear. We have previously demonstrated elevated level of the oxidative stress marker 8-isoprostaglandin F(2 alpha)(8-isoprostane) and lipids in pre-eclamptic decidual tissue. Arachidonic acid (AA) in tissue phospholipids is a source for 8-isoprostane generation, and 8-isoprostane is liberated from tissue phospholipids by phospholipase A(2)(PLA(2)). The aims of this study were to explore whether AA content or PLA(2)expression in pre-eclamptic decidual tissue differed from controls. Decidua basalis tissues were obtained by vacuum aspiration at Caesarean delivery in pre-eclamptic and control pregnancies. We demonstrated a statistically significantly higher total PLA(2)activity in pre-eclamptic decidua compared to control tissue. On the other hand, no differences in AA content of tissue phospholipids or protein expression of secretory and cytosolic PLA(2)between pre-eclamptic and control decidual tissue were found. In conclusion, the elevated level of free 8-isoprostane in pre-eclamptic decidual tissue could be caused by augmented PLA(2)activity. We speculate that an elevated PLA(2)enzyme activity in pre-eclamptic decidual tissue could be of importance in the pathogenesis of 'acute atherosis', comparable to the atherogenesis in cardiovascular diseases.
ISSN:0143-4004
1532-3102
DOI:10.1016/S0143-4004(03)00175-9