Difference in urinary 11-dehydro TXB2 and LTE4 excretion in patients with rheumatoid arthritis

Thromboxane and leukotrienes have been implicated in inflammation. However, the production level of these eicosanoids in patients with rheumatoid arthritis is still unclarified. In the present study, endogenous synthesis of thromboxane and cysteinyl leukotrienes in patients was investigated. The pro...

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2001-11, Vol.65 (5-6), p.301-306
Main Authors: Nakamura, H., Hishinuma, T., Suzuki, N., Chiba, S., Tsukamoto, H., Takabatake, M., Sawai, T., Mitomo, T., Inoue, H., Matsumoto, F., Mizugaki, M.
Format: Article
Language:English
Subjects:
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - urine
Biological and medical sciences
Creatinine - urine
Humans
Leukotriene E4 - urine
Middle Aged
Reference Values
Steroids - therapeutic use
Thromboxane A2 - metabolism
Thromboxane B2 - analogs & derivatives
Thromboxane B2 - urine
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Summary:Thromboxane and leukotrienes have been implicated in inflammation. However, the production level of these eicosanoids in patients with rheumatoid arthritis is still unclarified. In the present study, endogenous synthesis of thromboxane and cysteinyl leukotrienes in patients was investigated. The production of eicosanoids in patients is assessed by measuring stable urinary metabolites, 11-dehydro thromboxane B2 and leukotriene E4, using gas chromatography/selected ion monitoring and liquid chromatography/tandem mass spectrometry. The level of urinary thromboxane in patients was significantly higher than that in healthy volunteers (P
ISSN:0952-3278
1532-2823
DOI:10.1054/plef.2001.0329