Characterisation of biomolecular profiles in primary high-grade prostate cancer treated by radical prostatectomy

• Published in: Journal of cancer research and clinical oncology 2003-11, Vol.129 (11), p.662-668
• Main Authors: AUGUSTIN, Herbert, HAMMERER, Peter G, GRAEFEN, Markus, PALISAAR, Jüri, DAGHOFER, Fedor, HULAND, Hartwig, ERBERSDOBLER, Andreas
• Format: Article
• Language: English
• Subjects: Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Age Factors; Antigens; Biological and medical sciences; Biology; Biomarkers, Tumor; Case-Control Studies; Chromogranin A; Chromogranins - analysis; Humans; Immunohistochemistry; Ki-67 Antigen - analysis; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Prognosis; Prostate cancer; Prostate-Specific Antigen - blood; Prostatectomy; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Serotonin - analysis; Tumors of the urinary system; Urinary tract. Prostate gland
• ISSN: 0171-5216; 1432-1335
• DOI: 10.1007/s00432-003-0496-9

The aim of this study was to compare the biomolecular profile of high-grade (HG) with low-grade (LG) prostate cancers matched by preoperative serum prostate-specific antigen (PSA) levels. From 2,560 patients undergoing radical prostatectomy for localised disease, 24 men with HG cancer (Gleason score > or =9) were eligible. Their clinical data were compared with those of 24 LG tumours (Gleason score < or =6), matched by PSA values. The expression of Ki-67, p53, Bcl-2, chromogranin A, alpha-catenin, and PSA were analysed and compared between both groups. The expression of Ki-67 (P=0.031), p53 (P=0.008), Bcl-2 (P=0.002), and chromogranin A (P=0.042) were expressed significantly higher, and alpha-catenin (P=0.020) and PSA (P