Multiple myeloma following an episode of community acquired pneumococcal bacteraemia or meningitis

The risk of multiple myeloma subsequent to an episode of serious pneumococcal infection has not been ascertained. We identified 328 episodes of community‐acquired pneumococcal bacteraemia and 77 episodes of pneumococcal meningitis in 227,000 persons over 40 years of age in the County of North Jutlan...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2001-11, Vol.109 (11), p.797-800
Main Authors: GREGERSEN, HENRIK, PEDERSEN, GITTE, SVENDSEN, NICOLAJ, THULSTRUP, ANE MARIE, SØRENSEN, HENRIK TOFT, CARL SCHØNHEYDER, HENRIK
Format: Article
Language:English
Subjects:
Adult
Aged
bacteraemia
Bacteremia - complications
Bacteremia - epidemiology
Bacterial diseases
Biological and medical sciences
Community-Acquired Infections - complications
Community-Acquired Infections - epidemiology
Denmark - epidemiology
Experimental bacterial diseases and models
Female
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
meningitis
Meningitis, Pneumococcal - complications
Meningitis, Pneumococcal - epidemiology
Middle Aged
Multiple myeloma
Multiple Myeloma - complications
Multiple Myeloma - epidemiology
Multiple Myeloma - etiology
Pneumococcal Infections - complications
Pneumococcal Infections - epidemiology
Registries
registry
Risk Factors
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcus pneumoniae
Time Factors
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Summary:The risk of multiple myeloma subsequent to an episode of serious pneumococcal infection has not been ascertained. We identified 328 episodes of community‐acquired pneumococcal bacteraemia and 77 episodes of pneumococcal meningitis in 227,000 persons over 40 years of age in the County of North Jutland, Denmark, in the period 1981 to 1996. The incidence rate of a subsequent diagnosis of multiple myeloma was determined by linkage to the Danish Cancer Registry. During 1,218 patientyears of follow‐up in the bacteraemia cohort, 7 cases of multiple myeloma were diagnosed compared with 0.13 cases expected (standardized incidence ratio (SIR) 53.5, 95% confidence interval 21.4‐111.4). During 444 patient‐years of follow‐up in the meningitis cohort, 4 cases of multiple myeloma were diagnosed compared with 0.05 cases expected (SIR 83.2, 95% confidence interval 22.6‐214.8). Patients who survive an episode of community‐acquired pneumococcal bacteraemia or meningitis are at increased risk of being diagnosed with multiple myeloma, but the absolute risk is low.
ISSN:0903-4641
1600-0463
DOI:10.1034/j.1600-0463.2001.d01-149.x