An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patients

We amplified sequences of the Chlamydia pneumoniae (C P) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P =0.00022...

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Bibliographic Details
Published in:Multiple sclerosis 2003-10, Vol.9 (5), p.467-471
Main Authors: Grimaldi, L ME, Pincherle, A, Martinelli-Boneschi, F, Filippi, M, Patti, F, Reggio, A, Franciotta, D, Allegra, L, Comi, G, Blasi, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Chlamydophila Infections - blood
Chlamydophila Infections - cerebrospinal fluid
Chlamydophila Infections - complications
Chlamydophila pneumoniae - genetics
Chlamydophila pneumoniae - isolation & purification
DNA, Bacterial - blood
DNA, Bacterial - cerebrospinal fluid
Female
Humans
Italy
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Multiple Sclerosis, Chronic Progressive - blood
Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid
Multiple Sclerosis, Chronic Progressive - microbiology
Multiple Sclerosis, Relapsing-Remitting - blood
Multiple Sclerosis, Relapsing-Remitting - cerebrospinal fluid
Multiple Sclerosis, Relapsing-Remitting - microbiology
Neurology
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Summary:We amplified sequences of the Chlamydia pneumoniae (C P) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P =0.00022). C P+ patients showed magnetic resonance imaging (MRI) evidence of more active disease (P =0.02) compared to CP-MS patients and tended to have an anticipation of age at disease onset (32.39-12 versus 28.59-10 years; P =ns) causing a longer disease duration (7.59-5 versus 4.49-4 years; P =0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that C P infection of the central nervous system (C NS) might affect disease course in a subgroup of MS patients.
ISSN:1352-4585
1477-0970
DOI:10.1191/1352458503ms944oa