Multiple-marker screening in human immunodeficiency virus–positive pregnant women: screen positivity rates with the triple and quad screens

• Published in: American journal of obstetrics and gynecology 2003-10, Vol.189 (4), p.973-976
• Main Authors: Yudin, Mark H, Prosen, Tracy L, Landers, Daniel V
• Format: Article
• Language: English
• Subjects: acquired immunodeficiency syndrome; Acquired Immunodeficiency Syndrome - blood; alpha-Fetoproteins - analysis; Biological and medical sciences; Biomarkers - analysis; Case-Control Studies; Chorionic Gonadotropin - blood; Estriol - blood; Female; Gynecology. Andrology. Obstetrics; HIV Infections - blood; HIV Seronegativity; HIV Seropositivity - blood; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Inhibins - blood; Management. Prenatal diagnosis; Medical sciences; multiple-marker screening test; Pregnancy; Pregnancy Complications, Infectious - blood; Pregnancy. Fetus. Placenta; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1067/S0002-9378(03)01053-6

The study was undertaken to determine the screen-positive rates of multiple-marker screening tests in pregnant women who are positive for human immunodeficiency virus (HIV) at our institution for open neural tube defects and aneuploidy, for both triple (α-fetoprotein, human chorionic gonadotropin [hCG], unconjugated estriol) and quad (α-fetoprotein, hCG, unconjugated estriol, inhibin A) screens, and to compare these rates with a matched control group. A 1:1 matched case-control study was performed comparing multiple marker screening test results in 34 HIV-positive women with age- and race-matched HIV-negative controls. Individual serum markers and screen positive rates for both the triple and quad screens were compared among the cases and controls. In each group, there were 19 women with triple screens and 15 with quad screens. Serum hCG multiples of the median were significantly higher in the HIV-positive compared with the HIV-negative women ( P = .033). There was no difference in screen positive rates between the cases and controls using the triple screen, but there was a significantly higher overall screen positive rate in the HIV-positive group when the quad screen was used (33% vs 7%, P = .046). There is a significantly higher rate of overall quad screen positivity on multiple-marker screening among HIV-positive women compared with a matched control group.