Structure and evolution of the mitochondrial DNA complete control region in the Drosophila subobscura subgroup

The complete A + T‐rich region of mitochondrial DNA (mtDNA) has been cloned and sequenced in the species of the Drosophila subobscura subgroup D. subobscura, D. madeirensis and D. guanche. Comparative analysis of these sequences with others already published has identified new sequence motifs that a...

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Bibliographic Details
Published in:Insect molecular biology 2001-12, Vol.10 (6), p.573-578
Main Authors: Brehm, A, Harris, D. J, Hernández, M, Cabrera, V. M, Larruga, J. M, Pinto, F. M, González, A. M
Format: Article
Language:English
Subjects:
Animals
AT Rich Sequence
Base Sequence
control region
DNA, Complementary
DNA, Mitochondrial
Drosophila
Drosophila - classification
Drosophila - genetics
Drosophila subobscura
Evolution, Molecular
Genes, Insect
insects
Locus Control Region
mitochondrial DNA
Molecular Sequence Data
Phylogeny
promoter
Sequence Homology, Nucleic Acid
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Summary:The complete A + T‐rich region of mitochondrial DNA (mtDNA) has been cloned and sequenced in the species of the Drosophila subobscura subgroup D. subobscura, D. madeirensis and D. guanche. Comparative analysis of these sequences with others already published has identified new sequence motifs that are conserved in Drosophila and other insects. A putative bi‐directional promoter and a stop signal are proposed to be involved in the primary mtDNA strand replication of Drosophila. This region strongly resolves relationships of the species included in a phylogenetic analysis, both for closely related species and also at deeper phylogenetic levels when only the left and central domains are taken into account.
ISSN:0962-1075
1365-2583
DOI:10.1046/j.0962-1075.2001.00295.x