Antifungal Effects Of Endodontic Medicaments

ABSTRACT The eradication of root canal infection is paramount in endodontic treatment. Because fungi are involved in some types of root canal infections, the purpose of this study was to investigate the antifungal effects of several medicaments against the following selected fungal species: Candida...

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Bibliographic Details
Published in:Australian endodontic journal 2001-12, Vol.27 (3), p.112-114
Main Authors: Siqueira Jr, José F., Rĉças, Isabela N., Magalhäes, Fernando A. C., De Uzeda, Milton
Format: Article
Language:English
Subjects:
Anti-Infective Agents, Local - pharmacology
Antifungal Agents - pharmacology
Calcium Hydroxide - pharmacology
Calcium Sulfate - pharmacology
Candida - drug effects
Chlorhexidine - analogs & derivatives
Chlorhexidine - pharmacology
Dental Pulp Diseases - drug therapy
Dental Pulp Diseases - microbiology
Dentistry
Humans
Microbial Sensitivity Tests
Mycoses - drug therapy
Root Canal Irrigants - pharmacology
Saccharomyces cerevisiae - drug effects
Zinc Oxide - pharmacology
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Summary:ABSTRACT The eradication of root canal infection is paramount in endodontic treatment. Because fungi are involved in some types of root canal infections, the purpose of this study was to investigate the antifungal effects of several medicaments against the following selected fungal species: Candida albicans, Candida glabrata, Candida guilliermondii, Candida parapsilosis, and Saccharomyces cerevisiae. The agar diffusion test was the method used. Calcium sulphate or zinc oxide in glycerin showed no inhibitory effects towards any selected fungal species. The pastes of calcium sulphate or calcium hydroxide in camphorated paramonochlorophenol (CPMC)/glycerin showed the most pronounced antifungal effects. Calcium hydroxide in glycerin or chlorhexidine, and chlorhexidine in a detergent also showed antifungal activity, which was, however, much lower than the pastes of calcium sulphate or calcium hydroxide in CPMC/glycerin. Strategies using medicaments that have antifungal effects may assist in the successful management of persistent or secondary endodontic infections caused by fungi.
ISSN:1329-1947
1747-4477
DOI:10.1111/j.1747-4477.2001.tb00471.x