Protein phosphatase 2A as a new target for morphogenetic studies in the chick limb

The family of ser/thr protein phosphatases 2A (PP2A) is a major regulator of cell proliferation and cell death and is critically involved in the maintenance of homeostasis. In order to analyse the importance of PP2A proteins in apoptotic and developmental processes, this review focuses on previous s...

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Bibliographic Details
Published in:Biochimie 2003-08, Vol.85 (8), p.753-762, Article 753
Main Authors: Viallet, Jean, Garcia, Alphonse, Weydert, André
Format: Article
Language:English
Subjects:
Animals
Bone Morphogenetic Proteins - genetics
Bone Morphogenetic Proteins - metabolism
Chick Embryo
Chick limb bud
Drosophila - embryology
Embryo, Nonmammalian
Limb Buds - enzymology
Morphogenesis
Morphogenesis - physiology
Okadaic acid
Phosphoprotein Phosphatases - physiology
PP2A
Protein Phosphatase 2
Signal Transduction
Wings, Animal - embryology
Wings, Animal - enzymology
Wings, Animal - growth & development
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Summary:The family of ser/thr protein phosphatases 2A (PP2A) is a major regulator of cell proliferation and cell death and is critically involved in the maintenance of homeostasis. In order to analyse the importance of PP2A proteins in apoptotic and developmental processes, this review focuses on previous studies concerning the role of PP2A in morphogenesis. We first analyse wing formation in Drosophila, a model for invertebrates, then chick limb bud, a model for vertebrates. We also present a pioneer experiment to illustrate the potential relevance of PP2A studies in BMP signalling during chicken development and we finally discuss the BMP downstream signalling pathways.
ISSN:0300-9084
1638-6183
DOI:10.1016/j.biochi.2003.09.009