Overweight individuals are at increased risk for thrombotic thrombocytopenic purpura

Our understanding of the pathophysiology of thrombotic thrombocytopenic purpura, TTP, has increased dramatically in the past few years with the identification of the role of ADAMTS13. Nonetheless, risk factors for the development of acute TTP are few. Informally, obesity was felt to be common in pat...

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Bibliographic Details
Published in:American journal of hematology 2003-11, Vol.74 (3), p.170-174
Main Authors: Nicol, Kathleen K., Shelton, Brent J., Knovich, Mary Ann, Owen, John
Format: Article
Language:English
Subjects:
Anemias. Hemoglobinopathies
Biological and medical sciences
Continental Population Groups
Diseases of red blood cells
Female
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
obesity
Obesity - complications
Obesity - mortality
Odds Ratio
Purpura, Thrombotic Thrombocytopenic - etiology
Purpura, Thrombotic Thrombocytopenic - mortality
Regression Analysis
Retrospective Studies
Risk Factors
Sex Factors
TTP
weight
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Summary:Our understanding of the pathophysiology of thrombotic thrombocytopenic purpura, TTP, has increased dramatically in the past few years with the identification of the role of ADAMTS13. Nonetheless, risk factors for the development of acute TTP are few. Informally, obesity was felt to be common in patients with TTP and so a formal study was undertaken to further define this association. We report our data in 105 patients with classical TTP as defined by thrombocytopenia and microangiopathic hemolytic anemia. We found that marked obesity is a previously unrecognized risk factor with an associated odds ratio of 7.6. Interestingly, despite this increased risk, obesity might well be associated with lower mortality, although this did not reach statistical significance. Am J. Hematol. 74:170–174, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.10418