Compromised Reproductive Function in Adult Female Mice Selectively Expressing Mutant ErbB-1 Tyrosine Kinase Receptors in Astroglia

The ErbB-1 tyrosine kinase receptor plays critical roles in regulating physiological functions. This receptor-mediated signaling in astroglia has been implicated in controlling female sexual development via activating neurons that release LH-releasing hormone (LHRH), the neuropeptide required for th...

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Bibliographic Details
Published in:Molecular endocrinology (Baltimore, Md.) Md.), 2003-11, Vol.17 (11), p.2365-2376
Main Authors: Li, Biao, Yang, Zhihui, Hou, Jingwen, McCracken, April, Jennings, M. Anita, Ma, Mark Y. J
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Astrocytes - drug effects
Astrocytes - metabolism
Brain - cytology
Brain - drug effects
Brain - metabolism
Ecdysone - pharmacology
Estrous Cycle
Female
Follicle Stimulating Hormone - blood
Gene Deletion
Gene Expression - drug effects
Gonadotropin-Releasing Hormone - genetics
Gonadotropin-Releasing Hormone - metabolism
Humans
Luteinizing Hormone - blood
Mice
Mice, Transgenic
Mutation - genetics
Organ Specificity
Ovary - metabolism
Phosphorylation
Receptor, Epidermal Growth Factor - antagonists & inhibitors
Receptor, Epidermal Growth Factor - genetics
Receptor, Epidermal Growth Factor - metabolism
Reproduction - genetics
Reproduction - physiology
RNA, Messenger - genetics
RNA, Messenger - metabolism
Signal Transduction
Time Factors
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Summary:The ErbB-1 tyrosine kinase receptor plays critical roles in regulating physiological functions. This receptor-mediated signaling in astroglia has been implicated in controlling female sexual development via activating neurons that release LH-releasing hormone (LHRH), the neuropeptide required for the secretion of LH. It remains unknown whether astroglial ErbB-1 receptors are necessary for maintaining normal adult reproductive function. Here we provide genetic evidence that astroglia-specific and time-controlled disruption of ErbB-1 receptor signaling by expressing mutant ErbB-1 receptors leads to compromised reproduction due to alteration in LHRH neuron-controlled secretion of LH in adult female mice. Therefore, astroglial ErbB-1 receptors are required for controlling LHRH neuronal function and thus maintaining adult reproduction, suggesting that compromised astroglial ErbB-1 signaling may also contribute to reproductive abnormalities in aging females.
ISSN:0888-8809
1944-9917
DOI:10.1210/me.2003-0023