Analysis of Lead in Tooth Enamel by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry

Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was used to determine the Pb/Ca ratios in the enamel of deciduous incisors, a biomarker of in utero Pb exposure, using pelletized bone certified reference materials (CRMs) as calibrants. The detection limit for Pb by LA-ICP-MS w...

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Bibliographic Details
Published in:Analytical Sciences 2003, Vol.19(10), pp.1413-1416
Main Authors: URYU, Tsutomu, YOSHINAGA, Jun, YANAGISAWA, Yukio, ENDO, Masahiko, TAKAHASHI, Junichi
Format: Article
Language:English
Subjects:
Adult
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Calcium - analysis
Calibration
Chemical and industrial products toxicology. Toxic occupational diseases
Dental Enamel - chemistry
Fundamental and applied biological sciences. Psychology
Humans
Inorganic compounds
Lead - analysis
Mass Spectrometry - methods
Medical sciences
Metals and various inorganic compounds
Molar
Other biological molecules
Reference Standards
Toxicology
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Summary:Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was used to determine the Pb/Ca ratios in the enamel of deciduous incisors, a biomarker of in utero Pb exposure, using pelletized bone certified reference materials (CRMs) as calibrants. The detection limit for Pb by LA-ICP-MS was 11 μg kg-1 demonstrating an adequate sensitivity for Pb in the teeth of unexposed individuals (0.1 - 10 mg kg-1). The precision for the Pb/Ca ratios in NIST SRM 1486 Bone Meal was 3.4%. The correlation between Pb/Ca ratios obtained by LA-ICP-MS and those obtained by a digestion method was highly significant. We found one point calibration by a CRM was applicable for the quantification of Pb in tooth enamel. This method will be valuable for the assessment of in utero Pb exposure levels.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.19.1413