A dual role for interleukin-1 in LTP in mouse hippocampal slices

Interleukin-1 (IL-1) exerts numerous effects in the central nervous system and has been implicated in synaptic plasticity. The objective of this study was to investigate the role of endogenous as well as exogenous IL-1 on long-term potentiation (LTP). Hippocampal slices incubated at 34–36 °C show en...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimmunology 2003-11, Vol.144 (1), p.61-67
Main Authors: Ross, Fiona M., Allan, Stuart M., Rothwell, Nancy J., Verkhratsky, Alexej
Format: Article
Language:English
Subjects:
Animals
Cytokines - biosynthesis
Cytokines - metabolism
Dose-Response Relationship, Immunologic
Female
Hippocampal slice
Hippocampus - immunology
Hippocampus - metabolism
Hippocampus - physiology
Humans
IL-1 receptor antagonist
In Vitro Techniques
Interleukin 1 Receptor Antagonist Protein
Interleukin-1
Interleukin-1 - biosynthesis
Interleukin-1 - metabolism
Interleukin-1 - physiology
Long-Term Potentiation - immunology
LTP
Male
Mice
Mice, Inbred C57BL
Rats
Receptors, Interleukin-1 - antagonists & inhibitors
Recombinant Proteins - pharmacology
Sialoglycoproteins - pharmacology
Synaptic plasticity
Up-Regulation - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Interleukin-1 (IL-1) exerts numerous effects in the central nervous system and has been implicated in synaptic plasticity. The objective of this study was to investigate the role of endogenous as well as exogenous IL-1 on long-term potentiation (LTP). Hippocampal slices incubated at 34–36 °C show enhanced levels of IL-1α and IL-1β compared to slices incubated at 21–24 °C. IL-1 inhibits LTP induced by theta-burst stimulation (TBS) at either temperature. IL-1 receptor antagonist (IL-1ra) had no effect on LTP at 21–24 °C, but displayed a concentration-dependent inhibition of LTP at 34–36 °C. Under control conditions, the magnitude of LTP was not temperature dependent. These data suggest that IL-1 is required for LTP under physiological conditions but at higher doses, as encountered in pathological conditions, IL-1 inhibits LTP.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2003.08.030