Langerhans cell histiocytosis with periorbital cellulitis

To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis. Interventional case report. A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days’ duration. A history of recent eye trauma was reported. Computed tomography showed a...

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Bibliographic Details
Published in:American journal of ophthalmology 2003-11, Vol.136 (5), p.939-942
Main Authors: Levy, Jaime, Monos, Tova, Kapelushnik, Joseph, Maor, Esther, Nash, Michael, Lifshitz, Tova
Format: Article
Language:English
Subjects:
Antigens, CD - metabolism
Antigens, CD1 - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Biological and medical sciences
Ceftriaxone - therapeutic use
Cellulitis - diagnosis
Cellulitis - metabolism
Cellulitis - therapy
Child, Preschool
Combined Modality Therapy
Female
Histiocytosis, Langerhans-Cell - diagnosis
Histiocytosis, Langerhans-Cell - metabolism
Histiocytosis, Langerhans-Cell - therapy
Humans
Immunohistochemistry
Medical prognosis
Medical sciences
Microscopy
Miscellaneous
Ophthalmology
Orbital Diseases - diagnosis
Orbital Diseases - metabolism
Orbital Diseases - therapy
S100 Proteins - metabolism
Spinal Diseases - diagnosis
Tomography, X-Ray Computed
Vertebrae
Vimentin - metabolism
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Summary:To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis. Interventional case report. A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days’ duration. A history of recent eye trauma was reported. Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants. Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(03)00487-2