The role of electrical signaling via gap junctions in the generation of fast network oscillations

In recent years, several key studies have shed new light on the roles of electrical signaling via gap junctions between neurons in the adult brain. In particular, it is now clear that electrical signaling is important, if not essential, for the generation of a wide variety of different network inter...

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Bibliographic Details
Published in:Brain Research Bulletin 2003-11, Vol.62 (1), p.3-13
Main Authors: LeBeau, Fiona E.N., Traub, Roger D., Monyer, Hannah, Whittington, Miles A., Buhl, Eberhard H.
Format: Article
Language:English
Subjects:
Animals
Connexin
Connexins - metabolism
Cortical Synchronization
Electric Conductivity
Electrical synapses
Electroencephalography
Gamma oscillation
Gap Junction delta-2 Protein
Gap Junctions - physiology
Hippocampus
Hippocampus - cytology
Hippocampus - physiology
Humans
Models, Neurological
Nerve Net - physiology
Neurons - classification
Neurons - physiology
Ripples
Signal Transduction - physiology
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Summary:In recent years, several key studies have shed new light on the roles of electrical signaling via gap junctions between neurons in the adult brain. In particular, it is now clear that electrical signaling is important, if not essential, for the generation of a wide variety of different network interactions which may underlie rhythmic activity, of cognitive relevance, seen in EEG recordings. Two types of such rhythmic activity observed in the hippocampus both in vivo and in vitro are gamma frequency (30–80 Hz) oscillations and ultrafast (>80 Hz) “ripple” oscillations. Several lines of work, discussed here, show that gap junction-mediated signaling plays a central role in the generation of both these types of network activity. Recent work also now suggests that a number of different, anatomically discrete, gap junction-mediated networks may exist which could both function and be modulated independently.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2003.07.004