Adrenal cortical carcinoma

Adrenal cortical carcinoma is a rare endocrine tumor, and complete surgical resection is the only potentially curative treatment. Accurate preoperative biochemical and radiographic evaluation of the patient who presents with an adrenal mass optimizes patient management and facilitates a complete mar...

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Bibliographic Details
Published in:Current treatment options in oncology 2001-07, Vol.2 (4), p.355-364
Main Authors: Boushey, R P, Dackiw, A P
Format: Article
Language:English
Subjects:
Adrenal Cortex Neoplasms - complications
Adrenal Cortex Neoplasms - epidemiology
Adrenal Cortex Neoplasms - metabolism
Adrenal Cortex Neoplasms - surgery
Adrenalectomy - methods
Adult
Algorithms
Antineoplastic Agents - therapeutic use
Carcinoma - complications
Carcinoma - epidemiology
Carcinoma - metabolism
Carcinoma - surgery
Chemotherapy
Chemotherapy, Adjuvant
Child, Preschool
Clinical trials
Combined Modality Therapy
Cushing Syndrome - drug therapy
Cushing Syndrome - etiology
Epidemiologic Methods
Female
Humans
Hyperaldosteronism - drug therapy
Hyperaldosteronism - etiology
Incidence
Male
Middle Aged
Mineralocorticoids - administration & dosage
Mitotane - therapeutic use
Neuroendocrine tumors
Patients
Spironolactone - therapeutic use
Steroids - metabolism
Treatment Outcome
Tumors
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Description
Summary:Adrenal cortical carcinoma is a rare endocrine tumor, and complete surgical resection is the only potentially curative treatment. Accurate preoperative biochemical and radiographic evaluation of the patient who presents with an adrenal mass optimizes patient management and facilitates a complete margin-negative resection of the primary tumor--the most important prognostic variable for long-term survival. Response to mitotane or chemotherapy is modest in patients with advanced disease. It is hoped that an improved understanding of the molecular pathogenesis of this challenging tumor will lead to the development of novel treatment strategies.
ISSN:1527-2729
1534-6277
1534-5277
DOI:10.1007/s11864-001-0029-1