Synthesis and DNA-binding affinity of A-C8/ C-C2 alkoxyamido-linked pyrrolo[2,1- c][1,4]benzodiazepine dimers

The synthesis of new A-C8/ C-C2 alkoxyamido-linked pyrrolo[2,1- c][1,4]-benzodiazepine dimers have been described in this report. These dimers exhibit significant DNA-binding ability with moderate anticancer activity. Graphic

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2003-11, Vol.13 (22), p.3955-3958
Main Authors: Kamal, Ahmed, Ramulu, P., Srinivas, O., Ramesh, G.
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - chemical synthesis
Benzodiazepines - chemical synthesis
Benzodiazepines - pharmacology
Binding Sites
Biological and medical sciences
Dimerization
DNA - chemistry
DNA - drug effects
DNA - metabolism
General aspects
Medical sciences
Nucleic Acid Denaturation
Pharmacology. Drug treatments
Pyrroles - chemical synthesis
Pyrroles - pharmacology
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Description
Summary:The synthesis of new A-C8/ C-C2 alkoxyamido-linked pyrrolo[2,1- c][1,4]-benzodiazepine dimers have been described in this report. These dimers exhibit significant DNA-binding ability with moderate anticancer activity. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2003.08.071