Dopaminergic degeneration and perfusional impairment in Lewy body dementia and Alzheimer's disease

The clinical differentiation of Lewy body dementia (LBD) from Alzheimer's disease (AD) may be difficult. The aim of the present study was to assess the dopamine transporter function and the perfusional pattern in LBD and AD in vivo. Twenty patients with probable LBD and 24 with probable AD unde...

Full description

Saved in:
Bibliographic Details
Published in:Neurological sciences 2003-10, Vol.24 (3), p.162-163
Main Authors: Ceravolo, R, Volterrani, D, Gambaccini, G, Rossi, C, Logi, C, Manca, G, Berti, C, Mariani, G, Murri, L, Bonuccelli, U
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - diagnosis
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Cerebrovascular Circulation
Dementia
Diagnosis, Differential
Dopamine Plasma Membrane Transport Proteins
Female
Functional Laterality
Humans
Iodine Radioisotopes
Lewy Body Disease - diagnosis
Lewy Body Disease - metabolism
Lewy Body Disease - physiopathology
Male
Membrane Glycoproteins
Membrane Transport Proteins - metabolism
Mental Status Schedule
Nerve Tissue Proteins
Neurology
Neuropsychological Tests
Neurosciences
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon - methods
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The clinical differentiation of Lewy body dementia (LBD) from Alzheimer's disease (AD) may be difficult. The aim of the present study was to assess the dopamine transporter function and the perfusional pattern in LBD and AD in vivo. Twenty patients with probable LBD and 24 with probable AD underwent on 2 separate days a brain perfusional SPECT with 99mTc-ECD and a SPECT with (123)I-FP-CIT, a ligand of dopamine transporter. In LBD a significantly ( p
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-003-0110-6