Autoantibody appearance in cytomegalovirus-infected liver transplant recipients: Correlation with antigenemia

The presence of anti‐endothelial cells (AECA), smooth muscle (SMA), antinuclear (ANA) and antimitochondrial (AMA) autoantibodies, and liver/kidney microsomal antibody type 1 (LKM1) was investigated retrospectively in sera of liver transplant patients and correlated with cytomegalovirus (CMV) infecti...

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Bibliographic Details
Published in:Journal of medical virology 2002-01, Vol.66 (1), p.56-62
Main Authors: Varani, Stefania, Muratori, Luigi, De Ruvo, Nicola, Vivarelli, Marco, Lazzarotto, Tiziana, Gabrielli, Liliana, Bianchi, Francesco B., Bellusci, Roberto, Landini, Maria P.
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantibodies - immunology
Autoimmunity
Biological and medical sciences
Cell Membrane - immunology
Cytomegalovirus
Cytomegalovirus - isolation & purification
cytomegalovirus infection
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - virology
Endothelium - immunology
Female
Fundamental and applied biological sciences. Psychology
Graft Rejection
Human cytomegalovirus
Humans
Liver Transplantation - adverse effects
Liver Transplantation - immunology
Male
Microbiology
Middle Aged
Phosphoproteins - blood
transplantation
Viral Matrix Proteins - blood
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Summary:The presence of anti‐endothelial cells (AECA), smooth muscle (SMA), antinuclear (ANA) and antimitochondrial (AMA) autoantibodies, and liver/kidney microsomal antibody type 1 (LKM1) was investigated retrospectively in sera of liver transplant patients and correlated with cytomegalovirus (CMV) infection as determined by the antigenemia test and with the appearance of acute or chronic allograft rejection. Indirect immunofluorescence analysis was carried out in sequential sera from 40 liver transplant patients. Ten out of 23 antigenemia‐positive and none of the antigenemia‐negative patients developed serum autoantibodies (P = 0.002, Fisher's exact test). Anti‐endothelial cell autoantibodies were found in nine cases and SMA in four patients. Antinuclear antibodies were detected in one otherwise autoantibody‐negative patient. All but one case of autoantibody positivity were observed in the high antigenemia group (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.2111