Endogenous Sex Hormones and Cardiovascular Disease in Men

Unlike women, men do not experience an abrupt reduction in endogenous sex hormone production. It has, however, become clear that an age-associated decrease in the levels of (bioactive) sex hormones does occur. Whether endogenous sex hormones have an impact on cardiovascular disease has for many year...

Full description

Saved in:
Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2003-11, Vol.88 (11), p.5076-5086
Main Authors: Muller, Majon, van der Schouw, Yvonne T., Thijssen, Jos H. H., Grobbee, Diederick E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Cardiopathies: etiologic forms (general aspects and miscellaneous)
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - metabolism
Dehydroepiandrosterone - metabolism
Heart
Humans
Male
Medical sciences
Risk Factors
Testosterone - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Unlike women, men do not experience an abrupt reduction in endogenous sex hormone production. It has, however, become clear that an age-associated decrease in the levels of (bioactive) sex hormones does occur. Whether endogenous sex hormones have an impact on cardiovascular disease has for many years remained largely unknown, but during the last decade more attention has been drawn to the importance of testosterone, estrogens, and adrenal androgens in etiology, prevention, and treatment of male cardiovascular disease. The purpose of this article is to summarize the evidence currently available on the association between endogenous sex hormones and cardiovascular disease in males. Published studies dealing with the relationship between circulating levels of sex hormones and cardiovascular disease in males were reviewed. The studies reviewed in this article suggest that circulating endogenous sex hormones and estrogens have a neutral or beneficial effect on cardiovascular disease in men.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2003-030611