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Prediction of Bone Mass Density Variation by Bone Remodeling Markers in Postmenopausal Women with Vitamin D Insufficiency Treated with Calcium and Vitamin D Supplementation

The aim of this study was to determine whether early changes in bone markers could predict long-term response in bone mineral density (BMD) after calcium (500 mg) and vitamin D (400 IU) supplementation twice daily in ambulatory elderly women with vitamin D insufficiency (25-hydroxyvitamin D,

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Published in:	The journal of clinical endocrinology and metabolism 2003-11, Vol.88 (11), p.5175-5179
Main Authors:	Grados, Franck, Brazier, Michel, Kamel, Saïd, Mathieu, Marc, Hurtebize, Nathalie, Maamer, Mohamed, Garabédian, Michèle, Sebert, Jean-Luc, Fardellone, Patrice
Format:	Article
Language:	English
Subjects:	Aged Aged, 80 and over Biological and medical sciences Biomarkers Bone Density Bone Remodeling - drug effects Calcium - administration & dosage Diseases of the osteoarticular system Female General and cellular metabolism. Vitamins Humans Medical sciences Osteoporosis, Postmenopausal - drug therapy Osteoporosis. Osteomalacia. Paget disease Pharmacology. Drug treatments Postmenopause Predictive Value of Tests Treatment Outcome Vitamin D - administration & dosage Vitamin D Deficiency - drug therapy
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creator	Grados, Franck Brazier, Michel Kamel, Saïd Mathieu, Marc Hurtebize, Nathalie Maamer, Mohamed Garabédian, Michèle Sebert, Jean-Luc Fardellone, Patrice
description	The aim of this study was to determine whether early changes in bone markers could predict long-term response in bone mineral density (BMD) after calcium (500 mg) and vitamin D (400 IU) supplementation twice daily in ambulatory elderly women with vitamin D insufficiency (25-hydroxyvitamin D,
doi_str_mv	10.1210/jc.2002-021968
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One hundred and ninety-two women (mean age, 75 ± 7 yr) were randomized to receive either the supplementation (n = 95) or a placebo (n = 97) in a double-blind, controlled clinical trial for 1 yr. In comparison with the placebo group, supplementation significantly increased BMD, normalized 25-hydroxyvitamin D and significantly decreased intact PTH and bone remodeling markers. The initial values of telopeptide cross-links were correlated with improvement in total body BMD [urinary N-telopeptides (NTX), r = 0.38; C-telopeptides (CTX), r = 0.32; serum CTX, r = 0.28], and the 3-month changes in the same markers were correlated with improvement in total body (urinary N-telopeptides, r = −0.29; serum CTX, r = −0.26) and vertebral BMD (CTX, r = −0.26; all P < 0.05). We concluded that short-term changes in bone resorption markers can predict long-term variations in BMD in elderly women with vitamin D insufficiency receiving calcium and vitamin D supplementation.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2002-021968</identifier><identifier>PMID: 14602746</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers ; Bone Density ; Bone Remodeling - drug effects ; Calcium - administration & dosage ; Diseases of the osteoarticular system ; Female ; General and cellular metabolism. Vitamins ; Humans ; Medical sciences ; Osteoporosis, Postmenopausal - drug therapy ; Osteoporosis. Osteomalacia. Paget disease ; Pharmacology. Drug treatments ; Postmenopause ; Predictive Value of Tests ; Treatment Outcome ; Vitamin D - administration & dosage ; Vitamin D Deficiency - drug therapy</subject><ispartof>The journal of clinical endocrinology and metabolism, 2003-11, Vol.88 (11), p.5175-5179</ispartof><rights>Copyright © 2003 by The Endocrine Society</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4839-579651be8704b490d1f5bd5c8e24b036741d770d376f2bd1dc8a0e626972b0683</citedby><cites>FETCH-LOGICAL-c4839-579651be8704b490d1f5bd5c8e24b036741d770d376f2bd1dc8a0e626972b0683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15258435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14602746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grados, Franck</creatorcontrib><creatorcontrib>Brazier, Michel</creatorcontrib><creatorcontrib>Kamel, Saïd</creatorcontrib><creatorcontrib>Mathieu, Marc</creatorcontrib><creatorcontrib>Hurtebize, Nathalie</creatorcontrib><creatorcontrib>Maamer, Mohamed</creatorcontrib><creatorcontrib>Garabédian, Michèle</creatorcontrib><creatorcontrib>Sebert, Jean-Luc</creatorcontrib><creatorcontrib>Fardellone, Patrice</creatorcontrib><title>Prediction of Bone Mass Density Variation by Bone Remodeling Markers in Postmenopausal Women with Vitamin D Insufficiency Treated with Calcium and Vitamin D Supplementation</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>The aim of this study was to determine whether early changes in bone markers could predict long-term response in bone mineral density (BMD) after calcium (500 mg) and vitamin D (400 IU) supplementation twice daily in ambulatory elderly women with vitamin D insufficiency (25-hydroxyvitamin D, <12 ng/ml). One hundred and ninety-two women (mean age, 75 ± 7 yr) were randomized to receive either the supplementation (n = 95) or a placebo (n = 97) in a double-blind, controlled clinical trial for 1 yr. In comparison with the placebo group, supplementation significantly increased BMD, normalized 25-hydroxyvitamin D and significantly decreased intact PTH and bone remodeling markers. The initial values of telopeptide cross-links were correlated with improvement in total body BMD [urinary N-telopeptides (NTX), r = 0.38; C-telopeptides (CTX), r = 0.32; serum CTX, r = 0.28], and the 3-month changes in the same markers were correlated with improvement in total body (urinary N-telopeptides, r = −0.29; serum CTX, r = −0.26) and vertebral BMD (CTX, r = −0.26; all P < 0.05). We concluded that short-term changes in bone resorption markers can predict long-term variations in BMD in elderly women with vitamin D insufficiency receiving calcium and vitamin D supplementation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Bone Density</subject><subject>Bone Remodeling - drug effects</subject><subject>Calcium - administration & dosage</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Osteoporosis, Postmenopausal - drug therapy</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause</subject><subject>Predictive Value of Tests</subject><subject>Treatment Outcome</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D Deficiency - drug therapy</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFkU9v1DAQxSMEoqVw5Yh8gVsW23Hs5Ahb_lQqooJSuFmOPWG9dexgJ1rtd-JD4m5WKheEJcsaze89j-YVxXOCV4QS_HqrVxRjWmJKWt48KE5Jy-pSkFY8LE5zg5StoD9OiicpbTEmjNXV4-KEMI6pYPy0-H0VwVg92eBR6NHb4AF9Uimhc_DJTnt0o6JVh3a3X9pfYAgGnPU_MxlvISZkPboKaRrAh1HNSTn0PeQC7ey0QTd2UkMmztGFT3PfW23B6z26jqAmMAu0Vk7beUDKm78EX-dxdJCdpsMIT4tHvXIJnh3fs-Lb-3fX64_l5ecPF-s3l6VmTdWWtWh5TTpoBGYda7Ehfd2ZWjdAWYcrLhgxQmBTCd7TzhCjG4WBU55X1WHeVGfFq8V3jOHXDGmSg00anFMewpykIFXVNLT6L0haygk_OK4WUMeQUoRejtEOKu4lwfIuSLnV8i5IuQSZBS-OznM3gLnHj8ll4OURUEkr10fltU33XE3rhlV15tjC7YKbcla3bt5BlBtQbtpInA_joinz3xUhuSrzJW2W1YsMvAk6Wg9jhJTkNszR593_a-4_5YDItQ</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Grados, Franck</creator><creator>Brazier, Michel</creator><creator>Kamel, Saïd</creator><creator>Mathieu, Marc</creator><creator>Hurtebize, Nathalie</creator><creator>Maamer, Mohamed</creator><creator>Garabédian, Michèle</creator><creator>Sebert, Jean-Luc</creator><creator>Fardellone, Patrice</creator><general>Endocrine Society</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>200311</creationdate><title>Prediction of Bone Mass Density Variation by Bone Remodeling Markers in Postmenopausal Women with Vitamin D Insufficiency Treated with Calcium and Vitamin D Supplementation</title><author>Grados, Franck ; Brazier, Michel ; Kamel, Saïd ; Mathieu, Marc ; Hurtebize, Nathalie ; Maamer, Mohamed ; Garabédian, Michèle ; Sebert, Jean-Luc ; Fardellone, Patrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4839-579651be8704b490d1f5bd5c8e24b036741d770d376f2bd1dc8a0e626972b0683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Bone Density</topic><topic>Bone Remodeling - drug effects</topic><topic>Calcium - administration & dosage</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Osteoporosis, Postmenopausal - drug therapy</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Pharmacology. 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One hundred and ninety-two women (mean age, 75 ± 7 yr) were randomized to receive either the supplementation (n = 95) or a placebo (n = 97) in a double-blind, controlled clinical trial for 1 yr. In comparison with the placebo group, supplementation significantly increased BMD, normalized 25-hydroxyvitamin D and significantly decreased intact PTH and bone remodeling markers. The initial values of telopeptide cross-links were correlated with improvement in total body BMD [urinary N-telopeptides (NTX), r = 0.38; C-telopeptides (CTX), r = 0.32; serum CTX, r = 0.28], and the 3-month changes in the same markers were correlated with improvement in total body (urinary N-telopeptides, r = −0.29; serum CTX, r = −0.26) and vertebral BMD (CTX, r = −0.26; all P < 0.05). We concluded that short-term changes in bone resorption markers can predict long-term variations in BMD in elderly women with vitamin D insufficiency receiving calcium and vitamin D supplementation.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>14602746</pmid><doi>10.1210/jc.2002-021968</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects	Aged Aged, 80 and over Biological and medical sciences Biomarkers Bone Density Bone Remodeling - drug effects Calcium - administration & dosage Diseases of the osteoarticular system Female General and cellular metabolism. Vitamins Humans Medical sciences Osteoporosis, Postmenopausal - drug therapy Osteoporosis. Osteomalacia. Paget disease Pharmacology. Drug treatments Postmenopause Predictive Value of Tests Treatment Outcome Vitamin D - administration & dosage Vitamin D Deficiency - drug therapy
title	Prediction of Bone Mass Density Variation by Bone Remodeling Markers in Postmenopausal Women with Vitamin D Insufficiency Treated with Calcium and Vitamin D Supplementation
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