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Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana

Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. T...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2003-11, Vol.11 (23), p.4945-4948
Main Authors: CHATTOPADHYAY, Sunil K, SANTHA KUMAR, T. R, MAULIK, Prakas R, SRIVASTAVA, Sachin, GARG, Ankur, SHARON, Ashoke, NEGI, Arvind S, KHANUJA, Suman Preet S
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Language:English
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Summary:Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2003.09.010