Hypertrophic cardiomyopathy and mtDNA depletion. Successful treatment with heart transplantation

Cardiomyopathy associated with a mitochondrial DNA depletion syndrome is a rare condition. We report on a child with a hypertrophic cardiomyopathy and a mitochondrial depletion syndrome who was successfully treated by heart transplantation, given the tissue-specific nature of her mitochondrial disor...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 2002, Vol.12 (1), p.56-59
Main Authors: Santorelli, F.M., Gagliardi, M.G., Dionisi-Vici, C., Parisi, F., Tessa, A., Carrozzo, R., Piemonte, F., Pfeiffer, K., Schägger, H., Bertini, E.
Format: Article
Language:English
Subjects:
Cardiomyopathy, Hypertrophic, Familial - genetics
Cardiomyopathy, Hypertrophic, Familial - surgery
DNA, Mitochondrial - analysis
Electron Transport Complex IV - analysis
Female
Heart Transplantation
Humans
Hypertrophic cardiomyopathy
Infant
Mitochondrial DNA depletion
Muscle, Skeletal - cytology
Myocardium - enzymology
Myocardium - pathology
Succinate Dehydrogenase - analysis
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Summary:Cardiomyopathy associated with a mitochondrial DNA depletion syndrome is a rare condition. We report on a child with a hypertrophic cardiomyopathy and a mitochondrial depletion syndrome who was successfully treated by heart transplantation, given the tissue-specific nature of her mitochondrial disorder.
ISSN:0960-8966
1873-2364
DOI:10.1016/S0960-8966(01)00248-6