Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration

Autopsy studies and animal experiments suggest that microglial inflammation contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS). Monocyte-chemoattractant protein (MCP-1) might play an important role in microglial recruitment. We studied MCP-1 levels in sera and cerebrospinal fluid...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimmunology 2003-11, Vol.144 (1), p.139-142
Main Authors: Wilms, H., Sievers, J., Dengler, R., Bufler, J., Deuschl, G., Lucius, R.
Format: Article
Language:English
Subjects:
Age of Onset
Aged
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - cerebrospinal fluid
Amyotrophic Lateral Sclerosis - immunology
Amyotrophic Lateral Sclerosis - pathology
Analysis of Variance
Cell Movement - immunology
Cerebrospinal fluid
Cerebrospinal Fluid Proteins - biosynthesis
Cerebrospinal Fluid Proteins - blood
Cerebrospinal Fluid Proteins - cerebrospinal fluid
Chemokine CCL2 - biosynthesis
Chemokine CCL2 - blood
Chemokine CCL2 - cerebrospinal fluid
ELISA
Humans
Microglia
Microglia - immunology
Microglia - metabolism
Microglia - pathology
Middle Aged
Monocyte chemoattractant protein-1
Regression Analysis
Statistics, Nonparametric
Up-Regulation - immunology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autopsy studies and animal experiments suggest that microglial inflammation contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS). Monocyte-chemoattractant protein (MCP-1) might play an important role in microglial recruitment. We studied MCP-1 levels in sera and cerebrospinal fluid of 29 ALS patients and compared the results with 11 control patients with tension headache. The MCP-1 level was determined using enzyme-linked immunosorbent assays (ELISA). A significant increase in cerebrospinal fluid MCP-1 level but not serum level was seen in the patients with ALS compared to the control subjects. These results suggest that cerebrospinal fluid MCP-1 activity may be a sensitive marker for neuroinflammation in ALS useful for monitoring treatment trials in ALS.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2003.08.042