Basaloid in contrast to nonbasaloid head and neck squamous cell carcinomas display aberrations especially in cell cycle control genes

Background. At present, the differences between head and neck basaloid squamous cell carcinoma (BSCC) and nonbasaloid squamous cell carcinoma (SCC) are mostly on the basis of histologic and immunohistologic findings. Methods. In this study, we investigated 8 BSCCs and 59 SCCs for loss of heterozygos...

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Bibliographic Details
Published in:Head & neck 2003-11, Vol.25 (11), p.904-910
Main Authors: Poetsch, Micaela, Lorenz, Gerd, Bankau, Alexander, Kleist, Britta
Format: Article
Language:English
Subjects:
Biological and medical sciences
BSCC
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - virology
Cyclin D1 - metabolism
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
DNA, Viral - analysis
Genes, cdc - physiology
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - virology
Humans
Immunohistochemistry
Laryngeal Neoplasms - genetics
LOH
Loss of Heterozygosity
Medical sciences
Microsatellite Repeats
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
p16
Papillomaviridae - genetics
Phosphoric Monoester Hydrolases - metabolism
PTEN Phosphohydrolase
SCC
Tumor Suppressor Proteins - metabolism
Tumors
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Summary:Background. At present, the differences between head and neck basaloid squamous cell carcinoma (BSCC) and nonbasaloid squamous cell carcinoma (SCC) are mostly on the basis of histologic and immunohistologic findings. Methods. In this study, we investigated 8 BSCCs and 59 SCCs for loss of heterozygosity (LOH) at chromosomes 5q, 9p, 9q, 10q, 11q, 13p, 17p, and 18q. In addition, we analyzed p16, PTEN, and CCND1 (cyclin D1) and investigated the HPV status. Immunohistochemically, the expression of MIB‐1, p16, p53, and cyclin D1 was determined. Results. Aberrations in the BSCCs were especially frequent at 9p and in the CCND1 gene. In contrast, alterations at 10q occurred almost exclusively in conventional SCCs. Obvious differences could be determined concerning the HPV status: HPV‐DNA was detected in all BSCCs but only in 17% of conventional SCCs. Conclusions. Although the number of investigated BSCCs is rather low and did not allow statistical conclusions, our results focus on certain differences between the molecular pathogenesis of BSCCs and SCCs. © 2003 Wiley Periodicals, Inc. Head and Neck 25: 000–000, 2003
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.10301