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Hydrodynamic function of polyurethane prosthetic heart valves: influences of Young's modulus and leaflet thickness
The development of flexible polyurethane heart valves has been hindered by material degradation in vivo. Low modulus polyurethane leaflets are regarded as desirable to achieve good hydrodynamic function. However, low modulus materials may suffer high strain accumulation, hence poor durability. Highe...
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| Published in: | Biomaterials 2002, Vol.23 (1), p.45-50 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c444t-c0cc80d25487be51187c52409306a59a9133a518b8112443b95f98d88e8b931e3 |
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| cites | cdi_FETCH-LOGICAL-c444t-c0cc80d25487be51187c52409306a59a9133a518b8112443b95f98d88e8b931e3 |
| container_end_page | 50 |
| container_issue | 1 |
| container_start_page | 45 |
| container_title | Biomaterials |
| container_volume | 23 |
| creator | Bernacca, Gillian M. O’Connor, Bernard Williams, David F Wheatley, David J. |
| description | The development of flexible polyurethane heart valves has been hindered by material degradation in vivo. Low modulus polyurethane leaflets are regarded as desirable to achieve good hydrodynamic function. However, low modulus materials may suffer high strain accumulation, hence poor durability. Higher modulus materials may improve durability, but may have poor hydrodynamic function.
This study examines the hydrodynamic behaviour of biostable polyurethane valves, varying Young's modulus from 5 to 63.6
MPa and mean leaflet thickness from 48–238
μm.
Parameters studied included mean pressure gradient, energy losses and regurgitation over 5 equivalent cardiac outputs (3.6, 4.9, 6.4, 8.0 and 9.6
l
min
−1). At low cardiac output, modulus was not significantly correlated with any parameter of valve opening. At 9.6
l
min
−1, modulus significantly influenced mean pressure gradient (
p=0.033). Mean leaflet thickness significantly correlated with mean pressure gradient and energy losses during forward flow at all cardiac outputs (
p |
| doi_str_mv | 10.1016/S0142-9612(01)00077-1 |
| format | article |
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This study examines the hydrodynamic behaviour of biostable polyurethane valves, varying Young's modulus from 5 to 63.6
MPa and mean leaflet thickness from 48–238
μm.
Parameters studied included mean pressure gradient, energy losses and regurgitation over 5 equivalent cardiac outputs (3.6, 4.9, 6.4, 8.0 and 9.6
l
min
−1). At low cardiac output, modulus was not significantly correlated with any parameter of valve opening. At 9.6
l
min
−1, modulus significantly influenced mean pressure gradient (
p=0.033). Mean leaflet thickness significantly correlated with mean pressure gradient and energy losses during forward flow at all cardiac outputs (
p<0.001).
This study demonstrates that, over a wide range of moduli, valve hydrodynamic function is not affected significantly by the material modulus. Leaflet thickness is a highly significant factor. Higher modulus elastomers in a range up to 32.5
MPa may be useful in prosthetic heart valve leaflet manufacture, retaining good hydrodynamic function while potentially extending the lifetime of the valve.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(01)00077-1</identifier><identifier>PMID: 11762853</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Heart Valve Prosthesis ; Hydrodynamic function ; Leaflet thickness ; Modulus ; Polyurethane ; Polyurethanes</subject><ispartof>Biomaterials, 2002, Vol.23 (1), p.45-50</ispartof><rights>2001 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-c0cc80d25487be51187c52409306a59a9133a518b8112443b95f98d88e8b931e3</citedby><cites>FETCH-LOGICAL-c444t-c0cc80d25487be51187c52409306a59a9133a518b8112443b95f98d88e8b931e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11762853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernacca, Gillian M.</creatorcontrib><creatorcontrib>O’Connor, Bernard</creatorcontrib><creatorcontrib>Williams, David F</creatorcontrib><creatorcontrib>Wheatley, David J.</creatorcontrib><title>Hydrodynamic function of polyurethane prosthetic heart valves: influences of Young's modulus and leaflet thickness</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The development of flexible polyurethane heart valves has been hindered by material degradation in vivo. Low modulus polyurethane leaflets are regarded as desirable to achieve good hydrodynamic function. However, low modulus materials may suffer high strain accumulation, hence poor durability. Higher modulus materials may improve durability, but may have poor hydrodynamic function.
This study examines the hydrodynamic behaviour of biostable polyurethane valves, varying Young's modulus from 5 to 63.6
MPa and mean leaflet thickness from 48–238
μm.
Parameters studied included mean pressure gradient, energy losses and regurgitation over 5 equivalent cardiac outputs (3.6, 4.9, 6.4, 8.0 and 9.6
l
min
−1). At low cardiac output, modulus was not significantly correlated with any parameter of valve opening. At 9.6
l
min
−1, modulus significantly influenced mean pressure gradient (
p=0.033). Mean leaflet thickness significantly correlated with mean pressure gradient and energy losses during forward flow at all cardiac outputs (
p<0.001).
This study demonstrates that, over a wide range of moduli, valve hydrodynamic function is not affected significantly by the material modulus. Leaflet thickness is a highly significant factor. Higher modulus elastomers in a range up to 32.5
MPa may be useful in prosthetic heart valve leaflet manufacture, retaining good hydrodynamic function while potentially extending the lifetime of the valve.</description><subject>Heart Valve Prosthesis</subject><subject>Hydrodynamic function</subject><subject>Leaflet thickness</subject><subject>Modulus</subject><subject>Polyurethane</subject><subject>Polyurethanes</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkUtv1DAUhS1ERYfCTwB5xWMR8PUjcdggVEFbqRILYMHKcuwbxpA4g-2MNP-epDOiy66urvSd-ziHkBfA3gGD-v03BpJXbQ38DYO3jLGmqeAR2YBudKVaph6TzX_knDzN-Tdbeib5E3IO0NRcK7Eh6frg0-QP0Y7B0X6OroQp0qmnu2k4zAnL1kakuzTlssWyMFu0qdC9HfaYP9AQ-2HG6DCvmp_THH-9znSc_DzMmdro6YC2H7DQsg3uT8Scn5Gz3g4Zn5_qBfnx5fP3y-vq9uvVzeWn28pJKUvlmHOaea6kbjpUsDzmFJesFay2qrUtCGEV6E4DcClF16q-1V5r1F0rAMUFeXWcuxz_d8ZczBiyw2FYHprmbBoQUjDFHwR5A6qWGhZQHUG32JET9maXwmjTwQAzayrmLhWzWm4YmLtUzKp7eVowdyP6e9UphgX4eARw8WMfMJnswuqqDwldMX4KD6z4B0nBnPA</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Bernacca, Gillian M.</creator><creator>O’Connor, Bernard</creator><creator>Williams, David F</creator><creator>Wheatley, David J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Hydrodynamic function of polyurethane prosthetic heart valves: influences of Young's modulus and leaflet thickness</title><author>Bernacca, Gillian M. ; O’Connor, Bernard ; Williams, David F ; Wheatley, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-c0cc80d25487be51187c52409306a59a9133a518b8112443b95f98d88e8b931e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Heart Valve Prosthesis</topic><topic>Hydrodynamic function</topic><topic>Leaflet thickness</topic><topic>Modulus</topic><topic>Polyurethane</topic><topic>Polyurethanes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernacca, Gillian M.</creatorcontrib><creatorcontrib>O’Connor, Bernard</creatorcontrib><creatorcontrib>Williams, David F</creatorcontrib><creatorcontrib>Wheatley, David J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernacca, Gillian M.</au><au>O’Connor, Bernard</au><au>Williams, David F</au><au>Wheatley, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrodynamic function of polyurethane prosthetic heart valves: influences of Young's modulus and leaflet thickness</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2002</date><risdate>2002</risdate><volume>23</volume><issue>1</issue><spage>45</spage><epage>50</epage><pages>45-50</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The development of flexible polyurethane heart valves has been hindered by material degradation in vivo. Low modulus polyurethane leaflets are regarded as desirable to achieve good hydrodynamic function. However, low modulus materials may suffer high strain accumulation, hence poor durability. Higher modulus materials may improve durability, but may have poor hydrodynamic function.
This study examines the hydrodynamic behaviour of biostable polyurethane valves, varying Young's modulus from 5 to 63.6
MPa and mean leaflet thickness from 48–238
μm.
Parameters studied included mean pressure gradient, energy losses and regurgitation over 5 equivalent cardiac outputs (3.6, 4.9, 6.4, 8.0 and 9.6
l
min
−1). At low cardiac output, modulus was not significantly correlated with any parameter of valve opening. At 9.6
l
min
−1, modulus significantly influenced mean pressure gradient (
p=0.033). Mean leaflet thickness significantly correlated with mean pressure gradient and energy losses during forward flow at all cardiac outputs (
p<0.001).
This study demonstrates that, over a wide range of moduli, valve hydrodynamic function is not affected significantly by the material modulus. Leaflet thickness is a highly significant factor. Higher modulus elastomers in a range up to 32.5
MPa may be useful in prosthetic heart valve leaflet manufacture, retaining good hydrodynamic function while potentially extending the lifetime of the valve.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>11762853</pmid><doi>10.1016/S0142-9612(01)00077-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2002, Vol.23 (1), p.45-50 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71343052 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Heart Valve Prosthesis Hydrodynamic function Leaflet thickness Modulus Polyurethane Polyurethanes |
| title | Hydrodynamic function of polyurethane prosthetic heart valves: influences of Young's modulus and leaflet thickness |
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