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A Prospective Study of Childhood Neurocognitive Functioning in Schizophrenic Patients and Their Siblings
OBJECTIVE: This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings. METHOD: Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 t...
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| Published in: | The American journal of psychiatry 2003-11, Vol.160 (11), p.2060-2062 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 2062 |
| container_issue | 11 |
| container_start_page | 2060 |
| container_title | The American journal of psychiatry |
| container_volume | 160 |
| creator | Niendam, Tara A. Bearden, Carrie E. Rosso, Isabelle M. Sanchez, Laura E. Hadley, Trevor Nuechterlein, Keith H. Cannon, Tyrone D. |
| description | OBJECTIVE: This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings. METHOD: Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 to 32 individuals who developed schizophrenia in adulthood, 25 of their nonschizophrenic siblings, and 201 demographically similar nonpsychiatric comparison subjects. Mixed model analysis was used to examine between-group differences in standardized scores on the subtests. RESULTS: The probands and unaffected siblings had lower scores for picture arrangement, vocabulary, and coding than the comparison subjects but differed from each other only on the coding subtest. CONCLUSIONS: Children who later developed schizophrenia and their siblings showed similar patterns of deficits involving spatial reasoning, verbal knowledge, perceptual-motor speed, and speeded processes of working memory. However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings. |
| doi_str_mv | 10.1176/appi.ajp.160.11.2060 |
| format | article |
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METHOD: Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 to 32 individuals who developed schizophrenia in adulthood, 25 of their nonschizophrenic siblings, and 201 demographically similar nonpsychiatric comparison subjects. Mixed model analysis was used to examine between-group differences in standardized scores on the subtests. RESULTS: The probands and unaffected siblings had lower scores for picture arrangement, vocabulary, and coding than the comparison subjects but differed from each other only on the coding subtest. CONCLUSIONS: Children who later developed schizophrenia and their siblings showed similar patterns of deficits involving spatial reasoning, verbal knowledge, perceptual-motor speed, and speeded processes of working memory. However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.160.11.2060</identifier><identifier>PMID: 14594759</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Age Factors ; Biological and medical sciences ; Child ; Childhood experiences ; Cognition & reasoning ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Cognition Disorders - genetics ; Comorbidity ; Female ; Humans ; Male ; Medical sciences ; Neurocognitive functioning ; Neuropsychological Tests - statistics & numerical data ; Patients ; Predictors ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - physiology ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - epidemiology ; Schizophrenia - genetics ; Schizophrenic Psychology ; Sibling studies ; Siblings ; Siblings - psychology ; USA ; Wechsler Scales - statistics & numerical data</subject><ispartof>The American journal of psychiatry, 2003-11, Vol.160 (11), p.2060-2062</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Nov 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a433t-dab199d915b69755b02b99ba97c8cebf7c3a3fab8810a40cda6a3b1bd874fc593</citedby><cites>FETCH-LOGICAL-a433t-dab199d915b69755b02b99ba97c8cebf7c3a3fab8810a40cda6a3b1bd874fc593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.160.11.2060$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.160.11.2060$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,2855,21626,21627,21628,23930,23931,25140,27924,27925,31000,77794,77799</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15252643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14594759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niendam, Tara A.</creatorcontrib><creatorcontrib>Bearden, Carrie E.</creatorcontrib><creatorcontrib>Rosso, Isabelle M.</creatorcontrib><creatorcontrib>Sanchez, Laura E.</creatorcontrib><creatorcontrib>Hadley, Trevor</creatorcontrib><creatorcontrib>Nuechterlein, Keith H.</creatorcontrib><creatorcontrib>Cannon, Tyrone D.</creatorcontrib><title>A Prospective Study of Childhood Neurocognitive Functioning in Schizophrenic Patients and Their Siblings</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings. METHOD: Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 to 32 individuals who developed schizophrenia in adulthood, 25 of their nonschizophrenic siblings, and 201 demographically similar nonpsychiatric comparison subjects. Mixed model analysis was used to examine between-group differences in standardized scores on the subtests. RESULTS: The probands and unaffected siblings had lower scores for picture arrangement, vocabulary, and coding than the comparison subjects but differed from each other only on the coding subtest. CONCLUSIONS: Children who later developed schizophrenia and their siblings showed similar patterns of deficits involving spatial reasoning, verbal knowledge, perceptual-motor speed, and speeded processes of working memory. However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Childhood experiences</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - genetics</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurocognitive functioning</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Patients</subject><subject>Predictors</subject><subject>Prospective Studies</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenic Psychology</subject><subject>Sibling studies</subject><subject>Siblings</subject><subject>Siblings - psychology</subject><subject>USA</subject><subject>Wechsler Scales - statistics & numerical data</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqFkU1rFDEYgIModl39ByJBsLfZ5nMyOZbFVqHYwlbwFpJMppNlNhmTmUL99Wa7i4Ue6ink5Xk_HwA-YrTCWNRnehz9Sm_HFa73kRVBNXoFFphTXglCmtdggRAileT01wl4l_O2fBEV5C04wYxLJrhcgP4c3qSYR2cnf-_gZprbBxg7uO790PYxtvCHm1O08S74R-JiDgWNwYc76APc2N7_iWOfXPAW3ujJuzBlqEMLb3vnE9x4MxQ2vwdvOj1k9-H4LsHPi6-362_V1fXl9_X5VaUZpVPVaoOlbCXmppaCc4OIkdJoKWxjnemEpZp22jQNRpoh2-paU4NN2wjWWS7pEpwe6o4p_p5dntTOZ-uGQQcX56wEpoyKhvwX5AILhCUu4Odn4DbOKZQlFCGIiTIKKxA7QLZcMyfXqTH5nU4PCiO196X2vlTxpYqvElF7XyXt07H2bHaufUo6CirAlyOgs9VDl3SwPj9xnHBSl8stAT5wj23-Dfhi878EtbFD</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Niendam, Tara A.</creator><creator>Bearden, Carrie E.</creator><creator>Rosso, Isabelle M.</creator><creator>Sanchez, Laura E.</creator><creator>Hadley, Trevor</creator><creator>Nuechterlein, Keith H.</creator><creator>Cannon, Tyrone D.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>A Prospective Study of Childhood Neurocognitive Functioning in Schizophrenic Patients and Their Siblings</title><author>Niendam, Tara A. ; Bearden, Carrie E. ; Rosso, Isabelle M. ; Sanchez, Laura E. ; Hadley, Trevor ; Nuechterlein, Keith H. ; Cannon, Tyrone D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a433t-dab199d915b69755b02b99ba97c8cebf7c3a3fab8810a40cda6a3b1bd874fc593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Childhood experiences</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - genetics</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurocognitive functioning</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Patients</topic><topic>Predictors</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenic Psychology</topic><topic>Sibling studies</topic><topic>Siblings</topic><topic>Siblings - psychology</topic><topic>USA</topic><topic>Wechsler Scales - statistics & numerical data</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niendam, Tara A.</creatorcontrib><creatorcontrib>Bearden, Carrie E.</creatorcontrib><creatorcontrib>Rosso, Isabelle M.</creatorcontrib><creatorcontrib>Sanchez, Laura E.</creatorcontrib><creatorcontrib>Hadley, Trevor</creatorcontrib><creatorcontrib>Nuechterlein, Keith H.</creatorcontrib><creatorcontrib>Cannon, Tyrone D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niendam, Tara A.</au><au>Bearden, Carrie E.</au><au>Rosso, Isabelle M.</au><au>Sanchez, Laura E.</au><au>Hadley, Trevor</au><au>Nuechterlein, Keith H.</au><au>Cannon, Tyrone D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Prospective Study of Childhood Neurocognitive Functioning in Schizophrenic Patients and Their Siblings</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>160</volume><issue>11</issue><spage>2060</spage><epage>2062</epage><pages>2060-2062</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: This study evaluated childhood cognitive functioning in individuals who later developed schizophrenia and in their unaffected siblings. METHOD: Through the National Collaborative Perinatal Project, seven subtests of the Wechsler Intelligence Scale for Children were administered at age 7 to 32 individuals who developed schizophrenia in adulthood, 25 of their nonschizophrenic siblings, and 201 demographically similar nonpsychiatric comparison subjects. Mixed model analysis was used to examine between-group differences in standardized scores on the subtests. RESULTS: The probands and unaffected siblings had lower scores for picture arrangement, vocabulary, and coding than the comparison subjects but differed from each other only on the coding subtest. CONCLUSIONS: Children who later developed schizophrenia and their siblings showed similar patterns of deficits involving spatial reasoning, verbal knowledge, perceptual-motor speed, and speeded processes of working memory. However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>14594759</pmid><doi>10.1176/appi.ajp.160.11.2060</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of psychiatry, 2003-11, Vol.160 (11), p.2060-2062 |
| issn | 0002-953X 1535-7228 |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); American Psychiatric Publishing Journals |
| subjects | Adolescent Adult Adult and adolescent clinical studies Age Factors Biological and medical sciences Child Childhood experiences Cognition & reasoning Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - genetics Comorbidity Female Humans Male Medical sciences Neurocognitive functioning Neuropsychological Tests - statistics & numerical data Patients Predictors Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - physiology Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - diagnosis Schizophrenia - epidemiology Schizophrenia - genetics Schizophrenic Psychology Sibling studies Siblings Siblings - psychology USA Wechsler Scales - statistics & numerical data |
| title | A Prospective Study of Childhood Neurocognitive Functioning in Schizophrenic Patients and Their Siblings |
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