Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat

Although moderate fibrosis is a histological hallmark of the aging liver, the molecular mechanisms underlying this phenomenon are little known. Here, we provide a comprehensive description of hepatic collagen expression and metabolism during natural aging in rats. Interstitial collagen accumulated s...

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Bibliographic Details
Published in:Mechanisms of ageing and development 2002-02, Vol.123 (4), p.413-425
Main Authors: Gagliano, Nicoletta, Arosio, Beatrice, Grizzi, Fabio, Masson, Serge, Tagliabue, Jacopo, Dioguardi, Nicola, Vergani, Carlo, Annoni, Giorgio
Format: Article
Language:English
Subjects:
Aging
Aging - metabolism
Animals
Biological and medical sciences
Collagen Type I - genetics
Collagen Type I - metabolism
Collagen Type III - genetics
Collagen Type III - metabolism
Fibrosis
Gastroenterology. Liver. Pancreas. Abdomen
Gene Expression
Hydroxyproline - metabolism
Liver
Liver - metabolism
Liver - pathology
Liver Cirrhosis - metabolism
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 2 - metabolism
Matrix metalloproteinases
Medical sciences
Organ Size
Other diseases. Semiology
Rats
Rats, Sprague-Dawley
Tissue Inhibitor of Metalloproteinase-1 - metabolism
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta1
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Summary:Although moderate fibrosis is a histological hallmark of the aging liver, the molecular mechanisms underlying this phenomenon are little known. Here, we provide a comprehensive description of hepatic collagen expression and metabolism during natural aging in rats. Interstitial collagen accumulated significantly in the oldest animals, mainly in the periportal area ( P
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(01)00398-0