The muscle-specific marker desmin is expressed in a proportion of human dermal fibroblasts after their exposure to galectin-1

We have previously shown that galectin-1 is a factor capable of converting mouse dermal fibroblasts to the myogenic lineage [Cell Transplant 2000;9:519]. Here, we report that human dermal fibroblasts are also capable of expressing the myogenic marker, desmin, when grown in muscle-cell-conditioned me...

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Bibliographic Details
Published in:Neuromuscular disorders : NMD 2002-02, Vol.12 (2), p.183-186
Main Authors: Goldring, K, Jones, G.E, Sewry, C.A, Watt, D.J
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Animals
Biomarkers
Cells, Cultured
Culture Media, Conditioned
Desmin - analysis
Desmin - metabolism
Fetus
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - metabolism
Galectin 1
Gestational Age
Hemagglutinins - pharmacology
Human dermal fibroblast
Humans
Mice
Muscle conditioned media
Myogenic conversion
Skin - drug effects
Skin - metabolism
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Summary:We have previously shown that galectin-1 is a factor capable of converting mouse dermal fibroblasts to the myogenic lineage [Cell Transplant 2000;9:519]. Here, we report that human dermal fibroblasts are also capable of expressing the myogenic marker, desmin, when grown in muscle-cell-conditioned media. Furthermore, the human foetal skin cells also express this marker when grown in the presence of galectin-1. These results highlight the importance of galectin-1 in the conversion of both human and murine skin cells to a myogenic lineage. Thus galectin-1 could be an important tool for use in autologous cell therapies for the treatment of human muscular dystrophies.
ISSN:0960-8966
1873-2364
DOI:10.1016/S0960-8966(01)00280-2