Childhood and adolescent diabetes mellitus in Arabs residing in the United Arab Emirates

In 9 years (1990–1998), 40 Arab patients between the ages of 0 and 18 years had newly diagnosed diabetes mellitus (DM) at the Al-Ain hospital, United Arab Emirates (UAE). In this cohort, 35 patients had Type 1 DM while the remaining five patients had features of early onset Type 2 DM. For Type 1 DM...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2002, Vol.55 (1), p.29-33
Main Authors: Punnose, John, Agarwal, M.M., El Khadir, Ali, Devadas, K., Mugamer, I.T.
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Age of Onset
Arabs
Arabs - genetics
Biological and medical sciences
Blood Glucose - metabolism
Child
Child, Preschool
Childhood diabetes mellitus
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 2 - epidemiology
Diabetes. Impaired glucose tolerance
Diabetic Ketoacidosis - epidemiology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Follicle Stimulating Hormone - blood
Humans
Infant
Insulin - therapeutic use
Luteinizing Hormone - blood
Male
Medical sciences
Metabolic diseases
Middle East
Nuclear Family
Obesity
United Arab Emirates - epidemiology
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Summary:In 9 years (1990–1998), 40 Arab patients between the ages of 0 and 18 years had newly diagnosed diabetes mellitus (DM) at the Al-Ain hospital, United Arab Emirates (UAE). In this cohort, 35 patients had Type 1 DM while the remaining five patients had features of early onset Type 2 DM. For Type 1 DM patients, the mean age at diagnosis of was 9.2±4.1 years. At presentation, their mean plasma glucose was 27.6±11/mmol with 28 (80%) patients having diabetic ketoacidosis (DKA), both being much higher than generally reported in the West. The mean insulin requirement increased from 0.84±0.27 U/kg per 24 h (0–9-year group) to 1.02±0.33 U/kg per 24 h (10–18-year group), P=0.055. The home glucose monitoring and the glycaemic control of these Type 1 DM patients were sub-optimal with 28% of patients having recurrence of DKA. Among the Type 2 DM patients, four (80%) were obese with a positive family history of Type 2 DM. All of them initially responded to diet and oral hypoglycaemic drugs. Public education about DM in childhood and prevention of adolescent obesity remain major public health challenges in the UAE.
ISSN:0168-8227
1872-8227
DOI:10.1016/S0168-8227(01)00267-4