Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL)

We present the study of 16 cases of splenic marginal zone B-cell lymphoma (SMZBL) combining conventional cytogenetics and fluorescence in situ hybridization technique (FISH). We used a locus specific probe (11q22.3) that hybridizes with Ataxia Telangiectasia Mutated gene (ATM) and a centromeric prob...

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Bibliographic Details
Published in:Haematologica (Roma) 2003-11, Vol.88 (11), p.ELT33-ELT33
Main Authors: Salido, M, Astier, L, Puigdecanet, E, Espinet, B, Florensa, L, Sole, F
Format: Article
Language:English
Subjects:
Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins
Chromosome Painting
Chromosomes, Human, Pair 11 - genetics
DNA-Binding Proteins
Gene Deletion
Genes, Tumor Suppressor
Humans
Lymphoma, B-Cell - genetics
Lymphoma, Non-Hodgkin - genetics
Protein-Serine-Threonine Kinases - genetics
Splenic Neoplasms - genetics
Tumor Suppressor Proteins
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Summary:We present the study of 16 cases of splenic marginal zone B-cell lymphoma (SMZBL) combining conventional cytogenetics and fluorescence in situ hybridization technique (FISH). We used a locus specific probe (11q22.3) that hybridizes with Ataxia Telangiectasia Mutated gene (ATM) and a centromeric probe of chromosome 11 as a control. Deletions in ATM gene region have been found in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL) and have been considered as an independent prognosis factor in these pathologies. The aim of our study was to determine the ATM status in SMZBL because no specific studies concerning ATM status in SMZBL have been reported and other B-cell malignances have shown ATM deletions. No deletions were detected in any of the 16 cases. ATM deletions could be considered a rare event in SMZBCL.
ISSN:0390-6078
1592-8721