Chromatin dynamics: nucleosomes go mobile through twist defects

We study the spontaneous "sliding" of histone spools (nucleosomes) along DNA as a result of thermally activated single base pair twist defects. To this end we map the system onto a suitably extended Frenkel-Kontorova model. Combining results from several recent experiments we are able to e...

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Bibliographic Details
Published in:Physical review letters 2003-10, Vol.91 (14), p.148103-148103, Article 148103
Main Authors: Kulić, I M, Schiessel, H
Format: Article
Language:English
Subjects:
Chromatin - chemistry
Chromatin - genetics
DNA - chemistry
DNA - genetics
Histones - chemistry
Histones - genetics
Nucleic Acid Conformation
Nucleosomes - chemistry
Nucleosomes - genetics
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Summary:We study the spontaneous "sliding" of histone spools (nucleosomes) along DNA as a result of thermally activated single base pair twist defects. To this end we map the system onto a suitably extended Frenkel-Kontorova model. Combining results from several recent experiments we are able to estimate the nucleosome mobility without adjustable parameters. Our model shows also how the local mobility is intimately linked to the underlying base pair sequence.
ISSN:0031-9007
1079-7114
DOI:10.1103/physrevlett.91.148103