Glycoxidation and inflammation in chronic haemodialysis patients

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 2003-12, Vol.18 (12), p.2577-2581
• Main Authors: Kalousová, Marta, Sulková, Sylvie, Fialová, Lenka, Soukupová, Jiřina, Malbohan, Ivan Matouš, Špaček, Pavel, Braun, Martin, Mikulíková, Ludmila, Fořtová, Magdaléna, Hořejší, Magdaléna, Tesař, Vladimír, Zima, Tomáš
• Format: Article
• Language: English
• Subjects: Acute-Phase Proteins - immunology; Adult; advanced glycation end-products; advanced oxidation protein products; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Biomarkers - blood; carbonyl stress; Cross-Sectional Studies; Emergency and intensive care: renal failure. Dialysis management; Female; Glycation End Products, Advanced - blood; Glycation End Products, Advanced - immunology; Glycosylation; haemodialysis; Humans; Immune System Diseases - immunology; Immune System Diseases - physiopathology; inflammation; Intensive care medicine; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - immunology; Kidney Failure, Chronic - physiopathology; Kidney Failure, Chronic - therapy; Male; Medical sciences; Middle Aged; Oxidation-Reduction; oxidative stress; Oxidative Stress - immunology; Oxidative Stress - physiology; Renal Dialysis - adverse effects
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/gfg404

Background. Uraemia and haemodialysis treatment are associated with microinflammation and oxidative as well as carbonyl stress, which result in enhanced formation of glycoxidation products. Although both glycoxidation and inflammation can contribute to severe vascular and cardiovascular complications, the role that these pathogenic mechanisms play in the complex response of the whole organism remains to be elucidated. Methods. We performed a cross-sectional study in 34 clinically stable chronic haemodialysis patients and in 14 healthy controls while determining serum concentrations of pentosidine, fluorescent advanced glycation end-products (AGEs), advanced oxidation protein products (AOPPs) and acute phase reactants. We further assessed the relationship between these glycoxidation products and parameters of inflammation. Results. Glycoxidation products as well as certain acute phase reactants were elevated in haemodialysis patients. There were significant correlations between AOPPs and inflammatory parameters such as orosomucoid (0.39, P