Synthesis of N-Alkylated derivatives of imidazole as antibacterial agents

• Published in: Bioorganic & medicinal chemistry letters 2003-09, Vol.13 (17), p.2863-2865
• Main Authors: Khabnadideh, S., Rezaei, Z., Khalafi-Nezhad, A., Bahrinajafi, R., Mohamadi, R., Farrokhroz, A.A.
• Format: Article
• Language: English
• Subjects: Alkylation; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Escherichia coli - drug effects; Imidazoles - chemical synthesis; Imidazoles - chemistry; Imidazoles - pharmacology; Medical sciences; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pseudomonas aeruginosa - drug effects; Staphylococcus aureus - drug effects; Structure-Activity Relationship
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(03)00591-2

N-Alkylation of imidazole, 2-methylimidazole and 2-methyl-4-nitroimidazole have been carried out to achieve effective antibacterial agents. The products were then investigated for antibacterial activity against Escherichia coil, Staphylococcus aureus and Pseudomonas aeruginosa. Antibacterial effects of 1-alkylimidazole derivatives increase as the number of carbons in alkyl chain increases up to nine carbons. Also substitution of 2-methyl and 2-methyl-4-nitro groups on imidazole ring increases the antibacterial activity. Alkylated derivatives of imidazole have been synthesized as antibacterial agents. Antibacterial effects of 1-alkylimidazole derivatives increase as the number of carbons in alkyl chain increase up to nine carbons. Also substitution of 2-methyl and 2-methyl-4-nitro groups on imidazole ring increase the antibacterial activity.