Evidence of Estrogenic Effect by the Three-Month-Intervention of Isoflavone on Vaginal Maturation and Bone Metabolism in Early Postmenopausal Women

Objective of the present study is to determine the estrogenic effect of isoflavone on vaginal epithelia and bone metabolism in early postmenopausal women. Twenty-two postmenopausal women were randomly assigned to either a group that was given isoflavone extract (61.8 mg) for three months or a contro...

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Published in:ENDOCRINE JOURNAL 2003, Vol.50(5), pp.613-619
Main Authors: UESUGI, Takehiko, TODA, Toshiya, OKUHIRA, Takenori, CHEN, Jui-tung
Format: Article
Language:English
Subjects:
Amino Acids - urine
Bone and Bones - metabolism
Bone Density - drug effects
Bone metabolism
Drug Administration Schedule
Estrogens - administration & dosage
Female
Follicle Stimulating Hormone - blood
Humans
Isoflavone
Isoflavones - administration & dosage
Isoflavones - urine
Middle Aged
Postmenopausal women
Postmenopause - blood
Postmenopause - urine
Vagina - cytology
Vagina - drug effects
Vaginal differentiation
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Summary:Objective of the present study is to determine the estrogenic effect of isoflavone on vaginal epithelia and bone metabolism in early postmenopausal women. Twenty-two postmenopausal women were randomly assigned to either a group that was given isoflavone extract (61.8 mg) for three months or a control group that was given placebo. We measured the L2-4 bone mineral density (BMD) before and 3 months after treatment by dual X-ray absorptiometry (DXA). Blood and urine samples were obtained from the women before and 3 months after treatment. We measured FSH using radioimmunoassay and, urinary pyridinoline and deoxypyridinoline levels by HPLC. For endocrine cytology, vaginal smears were collected before and 3 months after the treatment. Three months after the treatment, the serum FSH levels and the BMD values did not significantly differ between the two groups. Urinary excretion of isoflavone was significantly higher in the group given isoflavone compared with that given placebo (p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.50.613