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Immunosuppressive constituents from Saussurea medusa
The methanol extract of Saussurea medusa Maxim afforded two lignans: 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1α-hydroxy-2α,4α-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13- epi-phaeophorbide-a and 13- epi-phaeophorbide-a methyl ester; one megastigmane...
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| Published in: | Phytochemistry (Oxford) 2002-01, Vol.59 (1), p.85-90 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c391t-aab9441155d12612914c3e3cfb284507f9cac4219b5fc1006948f3a873396bb53 |
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| cites | cdi_FETCH-LOGICAL-c391t-aab9441155d12612914c3e3cfb284507f9cac4219b5fc1006948f3a873396bb53 |
| container_end_page | 90 |
| container_issue | 1 |
| container_start_page | 85 |
| container_title | Phytochemistry (Oxford) |
| container_volume | 59 |
| creator | Duan, Hongquan Takaishi, Yoshihisa Momota, Hiroshi Ohmoto, Yasukazu Taki, Takao |
| description | The methanol extract of
Saussurea medusa Maxim afforded two lignans: 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1α-hydroxy-2α,4α-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-
epi-phaeophorbide-a and 13-
epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
Five new and 19 known compounds were isolated from the methanol extract of
Saussurea medusa Maxim. Their structures were determined by spectroscopic means. Two lignans showed a significant inhibitory effect on cytokine production. |
| doi_str_mv | 10.1016/S0031-9422(01)00429-0 |
| format | article |
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Saussurea medusa Maxim afforded two lignans: 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1α-hydroxy-2α,4α-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-
epi-phaeophorbide-a and 13-
epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
Five new and 19 known compounds were isolated from the methanol extract of
Saussurea medusa Maxim. Their structures were determined by spectroscopic means. Two lignans showed a significant inhibitory effect on cytokine production.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/S0031-9422(01)00429-0</identifier><identifier>PMID: 11754949</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject><![CDATA[Biological and medical sciences ; Bridged Bicyclo Compounds, Heterocyclic - isolation & purification ; Bridged Bicyclo Compounds, Heterocyclic - pharmacology ; Catechols - isolation & purification ; Catechols - pharmacology ; Chemical constitution ; Compositae ; Cytokines - antagonists & inhibitors ; Cytokines - biosynthesis ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Guaiacol - analogs & derivatives ; Guaiacol - isolation & purification ; Guaiacol - pharmacology ; Immunosuppressive activity ; Immunosuppressive Agents - isolation & purification ; Immunosuppressive Agents - pharmacology ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - metabolism ; Lignan ; Lignans - isolation & purification ; Lignans - pharmacology ; Medical sciences ; Phaeophorbide ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant physiology and development ; Saussurea - chemistry ; Saussurea medusa]]></subject><ispartof>Phytochemistry (Oxford), 2002-01, Vol.59 (1), p.85-90</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-aab9441155d12612914c3e3cfb284507f9cac4219b5fc1006948f3a873396bb53</citedby><cites>FETCH-LOGICAL-c391t-aab9441155d12612914c3e3cfb284507f9cac4219b5fc1006948f3a873396bb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13452701$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11754949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duan, Hongquan</creatorcontrib><creatorcontrib>Takaishi, Yoshihisa</creatorcontrib><creatorcontrib>Momota, Hiroshi</creatorcontrib><creatorcontrib>Ohmoto, Yasukazu</creatorcontrib><creatorcontrib>Taki, Takao</creatorcontrib><title>Immunosuppressive constituents from Saussurea medusa</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>The methanol extract of
Saussurea medusa Maxim afforded two lignans: 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1α-hydroxy-2α,4α-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-
epi-phaeophorbide-a and 13-
epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
Five new and 19 known compounds were isolated from the methanol extract of
Saussurea medusa Maxim. Their structures were determined by spectroscopic means. Two lignans showed a significant inhibitory effect on cytokine production.</description><subject>Biological and medical sciences</subject><subject>Bridged Bicyclo Compounds, Heterocyclic - isolation & purification</subject><subject>Bridged Bicyclo Compounds, Heterocyclic - pharmacology</subject><subject>Catechols - isolation & purification</subject><subject>Catechols - pharmacology</subject><subject>Chemical constitution</subject><subject>Compositae</subject><subject>Cytokines - antagonists & inhibitors</subject><subject>Cytokines - biosynthesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Guaiacol - analogs & derivatives</subject><subject>Guaiacol - isolation & purification</subject><subject>Guaiacol - pharmacology</subject><subject>Immunosuppressive activity</subject><subject>Immunosuppressive Agents - isolation & purification</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lignan</subject><subject>Lignans - isolation & purification</subject><subject>Lignans - pharmacology</subject><subject>Medical sciences</subject><subject>Phaeophorbide</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant physiology and development</subject><subject>Saussurea - chemistry</subject><subject>Saussurea medusa</subject><issn>0031-9422</issn><issn>1873-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkE1Lw0AQhhdRtFZ_gtKLoofozH4k3ZNI8aNQ8KCel81mAytNUneyBf-9qS169DSX552Z92HsDOEGAfPbVwCBmZacXwFeA0iuM9hjI5wWIhMFwD4b_SJH7JjoAwCUyvNDdoRYKKmlHjE5b5rUdpRWq-iJwtpPXNdSH_rk254mdeyayatNRCl6O2l8lciesIPaLsmf7uaYvT8-vM2es8XL03x2v8ic0Nhn1pZaSkSlKuQ5co3SCS9cXfKpVFDU2lknOepS1Q4Bci2ntbBDAaHzslRizC63e1ex-0yeetMEcn65tK3vEpkCheKSwwCqLehiRxR9bVYxNDZ-GQSz0WV-dJmNCwNofnSZTe58dyCVQ7W_1M7PAFzsAEvOLutoWxfojxNS8QJw4O62nB90rIOPhlzwrfNViN71purCP698A8tmhcc</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Duan, Hongquan</creator><creator>Takaishi, Yoshihisa</creator><creator>Momota, Hiroshi</creator><creator>Ohmoto, Yasukazu</creator><creator>Taki, Takao</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Immunosuppressive constituents from Saussurea medusa</title><author>Duan, Hongquan ; Takaishi, Yoshihisa ; Momota, Hiroshi ; Ohmoto, Yasukazu ; Taki, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-aab9441155d12612914c3e3cfb284507f9cac4219b5fc1006948f3a873396bb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Bridged Bicyclo Compounds, Heterocyclic - isolation & purification</topic><topic>Bridged Bicyclo Compounds, Heterocyclic - pharmacology</topic><topic>Catechols - isolation & purification</topic><topic>Catechols - pharmacology</topic><topic>Chemical constitution</topic><topic>Compositae</topic><topic>Cytokines - antagonists & inhibitors</topic><topic>Cytokines - biosynthesis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Guaiacol - analogs & derivatives</topic><topic>Guaiacol - isolation & purification</topic><topic>Guaiacol - pharmacology</topic><topic>Immunosuppressive activity</topic><topic>Immunosuppressive Agents - isolation & purification</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lignan</topic><topic>Lignans - isolation & purification</topic><topic>Lignans - pharmacology</topic><topic>Medical sciences</topic><topic>Phaeophorbide</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant physiology and development</topic><topic>Saussurea - chemistry</topic><topic>Saussurea medusa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duan, Hongquan</creatorcontrib><creatorcontrib>Takaishi, Yoshihisa</creatorcontrib><creatorcontrib>Momota, Hiroshi</creatorcontrib><creatorcontrib>Ohmoto, Yasukazu</creatorcontrib><creatorcontrib>Taki, Takao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytochemistry (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duan, Hongquan</au><au>Takaishi, Yoshihisa</au><au>Momota, Hiroshi</au><au>Ohmoto, Yasukazu</au><au>Taki, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppressive constituents from Saussurea medusa</atitle><jtitle>Phytochemistry (Oxford)</jtitle><addtitle>Phytochemistry</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>59</volume><issue>1</issue><spage>85</spage><epage>90</epage><pages>85-90</pages><issn>0031-9422</issn><eissn>1873-3700</eissn><abstract>The methanol extract of
Saussurea medusa Maxim afforded two lignans: 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1α-hydroxy-2α,4α-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-
epi-phaeophorbide-a and 13-
epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
Five new and 19 known compounds were isolated from the methanol extract of
Saussurea medusa Maxim. Their structures were determined by spectroscopic means. Two lignans showed a significant inhibitory effect on cytokine production.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>11754949</pmid><doi>10.1016/S0031-9422(01)00429-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | Phytochemistry (Oxford), 2002-01, Vol.59 (1), p.85-90 |
| issn | 0031-9422 1873-3700 |
| language | eng |
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| source | Elsevier |
| subjects | Biological and medical sciences Bridged Bicyclo Compounds, Heterocyclic - isolation & purification Bridged Bicyclo Compounds, Heterocyclic - pharmacology Catechols - isolation & purification Catechols - pharmacology Chemical constitution Compositae Cytokines - antagonists & inhibitors Cytokines - biosynthesis Fundamental and applied biological sciences. Psychology General pharmacology Guaiacol - analogs & derivatives Guaiacol - isolation & purification Guaiacol - pharmacology Immunosuppressive activity Immunosuppressive Agents - isolation & purification Immunosuppressive Agents - pharmacology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lignan Lignans - isolation & purification Lignans - pharmacology Medical sciences Phaeophorbide Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant physiology and development Saussurea - chemistry Saussurea medusa |
| title | Immunosuppressive constituents from Saussurea medusa |
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