Effect of carnosine on self-organization of mitochondrial assemblies in rat liver homogenate

The effect of carnosine on self-organization of mitochondrial assemblies was studied in rat liver homogenate of quiescent and excited animals. It was shown in separate electron microscopy experiments with serial slices that under our conditions of preparation of homogenate, blocks of native mitochon...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2003-09, Vol.68 (9), p.1002-1005
Main Authors: Zakharchenko, M V, Temnov, A V, Kondrashova, M N
Format: Article
Language:English
Subjects:
Animals
Carnosine - pharmacology
Epinephrine - pharmacology
Liver
Liver - cytology
Liver - drug effects
Liver - ultrastructure
Male
Mitochondria
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Mitochondria, Liver - ultrastructure
Rats
Rats, Wistar
Rodents
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Summary:The effect of carnosine on self-organization of mitochondrial assemblies was studied in rat liver homogenate of quiescent and excited animals. It was shown in separate electron microscopy experiments with serial slices that under our conditions of preparation of homogenate, blocks of native mitochondrial-reticular network in the cell, assemblies of mitochondria, are kept. Carnosine was shown to prevent dissociation of assemblies during storage. Its effect is maximal for more dissociated assemblies from excited animals with decreased ability for self-organization. Prevention of disassembly of organelles by carnosine can serve as one of the mechanisms of carnosine-induced diminishing of muscle fatigue under prolonged work.
ISSN:0006-2979
1608-3040
DOI:10.1023/A:1026064613289