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Effect of carnosine on self-organization of mitochondrial assemblies in rat liver homogenate

The effect of carnosine on self-organization of mitochondrial assemblies was studied in rat liver homogenate of quiescent and excited animals. It was shown in separate electron microscopy experiments with serial slices that under our conditions of preparation of homogenate, blocks of native mitochon...

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Published in:	Biochemistry (Moscow) 2003-09, Vol.68 (9), p.1002-1005
Main Authors:	Zakharchenko, M V, Temnov, A V, Kondrashova, M N
Format:	Article
Language:	English
Subjects:	Animals Carnosine - pharmacology Epinephrine - pharmacology Liver Liver - cytology Liver - drug effects Liver - ultrastructure Male Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondria, Liver - ultrastructure Rats Rats, Wistar Rodents
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container_issue	9
container_start_page	1002
container_title	Biochemistry (Moscow)
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creator	Zakharchenko, M V Temnov, A V Kondrashova, M N
description	The effect of carnosine on self-organization of mitochondrial assemblies was studied in rat liver homogenate of quiescent and excited animals. It was shown in separate electron microscopy experiments with serial slices that under our conditions of preparation of homogenate, blocks of native mitochondrial-reticular network in the cell, assemblies of mitochondria, are kept. Carnosine was shown to prevent dissociation of assemblies during storage. Its effect is maximal for more dissociated assemblies from excited animals with decreased ability for self-organization. Prevention of disassembly of organelles by carnosine can serve as one of the mechanisms of carnosine-induced diminishing of muscle fatigue under prolonged work.
doi_str_mv	10.1023/A:1026064613289
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subjects	Animals Carnosine - pharmacology Epinephrine - pharmacology Liver Liver - cytology Liver - drug effects Liver - ultrastructure Male Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondria, Liver - ultrastructure Rats Rats, Wistar Rodents
title	Effect of carnosine on self-organization of mitochondrial assemblies in rat liver homogenate
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