Developmental expression patterns of CCR5 and CXCR4 in the rhesus macaque brain

Emerging data indicate that chemokine receptors on neurons and glia in the central nervous system (CNS) play a role in normal CNS development, intercellular communication, and the neuropathogenesis of AIDS. To further understand chemokine receptors in the brain and explore their potential role in HI...

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Bibliographic Details
Published in:Journal of neuroimmunology 2002, Vol.122 (1), p.146-158
Main Authors: Westmoreland, S.V, Alvarez, X, deBakker, C, Aye, P, Wilson, M.L, Williams, K.C, Lackner, A.A
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Age Factors
Animals
Animals, Newborn
Brain
Brain Chemistry - immunology
CCR5
CCR5 protein
Chemokine receptors
CXCR4
CXCR4 protein
Fetus
Flow Cytometry
Frontal Lobe - cytology
Frontal Lobe - embryology
Frontal Lobe - immunology
Gene Expression Regulation, Developmental - immunology
Glia
HIV
Immunohistochemistry
Macaca mulatta
Macaque
Neuroglia - chemistry
Neuroglia - physiology
Neurons
Neurons - chemistry
Neurons - physiology
Receptors, CCR5 - analysis
Receptors, CCR5 - genetics
Receptors, Cell Surface - genetics
Receptors, CXCR4 - analysis
Receptors, CXCR4 - genetics
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - analysis
Simian Acquired Immunodeficiency Syndrome - immunology
SIV
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Summary:Emerging data indicate that chemokine receptors on neurons and glia in the central nervous system (CNS) play a role in normal CNS development, intercellular communication, and the neuropathogenesis of AIDS. To further understand chemokine receptors in the brain and explore their potential role in HIV neuropathogenesis, particularly in pediatrics, we examined the regional and cellular distribution of CCR5 and CXCR4 in normal fetal, neonatal, and adult rhesus macaques. CCR5 and CXCR4 were detected by immunohistochemistry and immunofluorescence within the cytoplasm of subpopulations of neurons in the neocortex, hippocampus, basal nuclei, thalamus, brain stem, and cerebellum and by flow cytometry on the surface of neurons and glia. Interestingly, expression of CCR5 and CXCR4 increased significantly ( p
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(01)00457-X