Secretory and vascular effects of adrenomedullin in gastric ulcer: role of CGRP- and adrenomedullin-receptors

Adrenomedullin prevents damage of gastric mucosa in either reserpine-treated or pylorus-ligated rats. Pre-treatment with CGRP 8–37 resulted in a decrease of the gastro-protective effect of adrenomedullin in both models and reversed the inhibitory effect of adrenomedullin on gastric acid output in th...

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Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2003-08, Vol.24 (8), p.1175-1180
Main Authors: Salomone, Salvatore, Caruso, Antonina, Martinez, Giuseppa, Cutuli, Vincenza Maria, Prato, Agata, Bianchi, Alfredo, Amico-Roxas, Matilde, Clementi, Giuseppe
Format: Article
Language:English
Subjects:
Adrenomedullin
Adrenomedullin 22–52
Animals
Anti-secretory effect
Biological and medical sciences
CGRP 8–37
Fundamental and applied biological sciences. Psychology
Gastric artery
Gastric ulcer
Humans
Male
Peptides - metabolism
Rats
Receptors, Adrenomedullin
Receptors, Calcitonin Gene-Related Peptide - metabolism
Receptors, Peptide - metabolism
Serotonin - metabolism
Stomach Ulcer - metabolism
Vertebrates: endocrinology
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Summary:Adrenomedullin prevents damage of gastric mucosa in either reserpine-treated or pylorus-ligated rats. Pre-treatment with CGRP 8–37 resulted in a decrease of the gastro-protective effect of adrenomedullin in both models and reversed the inhibitory effect of adrenomedullin on gastric acid output in the pylorus-ligated rats. These adrenomedullin actions were less effectively modified by pre-treatment with adrenomedullin 22–52. These data suggest that the anti-ulcer effect of adrenomedullin is mainly related to its anti-secretory action, presumably mediated through CGRP-receptors.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2003.06.006