In situ forming degradable networks and their application in tissue engineering and drug delivery

Multifunctional macromers based on poly(ethylene glycol) and poly(vinyl alcohol) were photopolymerized to form degradable hydrogel networks. The degradation behavior of the highly swollen gels was characterized by monitoring changes in their mass loss, degree of swelling, and compressive modulus. Ex...

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Bibliographic Details
Published in:Journal of controlled release 2002-01, Vol.78 (1), p.199-209
Main Authors: Anseth, Kristi S, Metters, Andrew T, Bryant, Stephanie J, Martens, Penny J, Elisseeff, Jennifer H, Bowman, Christopher N
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cartilage - physiology
Cartilage tissue engineering
Cattle
Degradation
General pharmacology
Glycosaminoglycans - analysis
Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism
Hydrogels
Hydrolysis
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Photopolymerization
Polyethylene Glycols - metabolism
Polyvinyl Alcohol - metabolism
Somatomedins - pharmacology
Tissue Engineering
Transforming Growth Factor beta - pharmacology
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Summary:Multifunctional macromers based on poly(ethylene glycol) and poly(vinyl alcohol) were photopolymerized to form degradable hydrogel networks. The degradation behavior of the highly swollen gels was characterized by monitoring changes in their mass loss, degree of swelling, and compressive modulus. Experimental results show that the modulus decreases exponentially with time, while the volumetric swelling ratio increases exponentially. A degradation mechanism assuming pseudo first-order hydrolysis kinetics and accounting for the structure of the crosslinked networks successfully predicted the experimentally observed trends in these properties with degradation. Once verified, the proposed degradation mechanism was extended to correlate network degradation kinetics, and subsequent changes in network structure, with release behavior of bioactive molecules from these dynamic systems. A theoretical model utilizing a statistical approach to predict the cleavage of crosslinks within the network was used to predict the complex erosion profiles produced by these hydrogels. Finally, the application of these macromers as in situ forming hydrogel constructs for cartilage tissue engineering is demonstrated.
ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(01)00500-4